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High sensitivity cardiac troponin T in patients not having an acute coronary syndrome: results from the TRAPID-AMI study
Henry Ford Hosp, Emergency Med, Detroit, MI USA..
Univ Hosp Base, Dept Cardiol, Basel, Switzerland.;Univ Hosp Base, Cardiovasc Res Inst Basel, Basel, Switzerland..
Univ Hosp Heidelberg, Dept Internal Med Cardiol Angiol & Pulm, Heidelberg, Germany..
Paracelsus Med Univ, Dept Emergency & Crit Care Med, Nurnberg, Germany..
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2017 (English)In: Biomarkers, ISSN 1354-750X, E-ISSN 1366-5804, Vol. 22, no 8, p. 709-714Article in journal (Refereed) Published
Abstract [en]

Purpose: To describe the baseline, 1hr and delta high sensitivity cardiac troponin (hs-cTnT) values in patients with suspected acute myocardial infarction (AMI) but without a final acute coronary syndrome (ACS) diagnosis.Materials and methods: hs-cTnT assay for RAPID rule out of acute myocardial infarction (TRAPID-AMI) was a prospective diagnostic trial that enrolled emergency department (ED) patients with suspected AMI. Final patient diagnoses were adjudicated by a clinical events committee and subjects placed in different clinical groups: AMI, unstable angina, non-ACS cardiac, non-cardiac and unknown origin. The baseline, 1hr and delta hs-cTnT values were analysed in the 902 non-ACS patients.Results: Amongst the 1282 studied the patient groups were 213 (17%) AMI, 167 (13%) unstable angina, 113 (9%) non-ACS cardiac, 288 (22%) non-cardiac and 501 (39%) unknown origin. The hs-cTnT values in the non-cardiac and unknown origin groups were combined. The median hs-cTnT values (ng/L) were higher (p<0.001) in the non-ACS cardiac compared to the non-cardiac/unknown origin group at baseline (11.8,<5) and 1hr (12.3,<5). Their negative predictive values were 0.955 (baseline) and 0.954 (1hr) for predicting non-ACS cardiac versus non-cardiac/unknown origin diagnoses.Conclusions: Hs-cTnT may help predict whether non-ACS ED patients have a final non-ACS cardiac or non-cardiac/unknown origin diagnoses.

Place, publisher, year, edition, pages
2017. Vol. 22, no 8, p. 709-714
Keywords [en]
High sensitivity troponin, non ACS patients, emergency department
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-343145DOI: 10.1080/1354750X.2017.1334154ISI: 000416064700002PubMedID: 28532247OAI: oai:DiVA.org:uu-343145DiVA, id: diva2:1185681
Available from: 2018-02-26 Created: 2018-02-26 Last updated: 2018-02-26Bibliographically approved

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