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Innovative exhaled breath analysis with old breathing manoeuvres-is there a problem or an advantage?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
2017 (English)In: Journal of Breath Research, ISSN 1752-7155, E-ISSN 1752-7163, Vol. 11, no 3, article id 031001Article in journal (Refereed) Published
Abstract [en]

As the field of exhaled breath research is expanding, the question that arises is can the old usual method of spirometry be used in all cases? The answer is yes for some analysation methods and definitely not for others: it all depends on the result you are looking for. Exhaled breath condensate collection can be accomplished with silent tidal breathing, but not in the analysation of the amount of exhaled particles, as they become very low during tidal breathing. There are gases that are exhalation flow dependent, e.g. nitric oxide, acetone and ethanol, that require a special breathing manoeuvre with flow control. Physiological changes of the lung, i.e. inhalation to total lung capacity or forced exhalation such as during spirometry, will affect the result of exhaled biomarkers. The standardisation of exhaled breath requires further development, and there are many aspects to consider.

Place, publisher, year, edition, pages
2017. Vol. 11, no 3, article id 031001
Keywords [en]
breath test, nitric oxide, volatile organic compounds, vital capacity
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-342412DOI: 10.1088/1752-7163/aa720bISI: 000404745400001PubMedID: 28660856OAI: oai:DiVA.org:uu-342412DiVA, id: diva2:1184184
Available from: 2018-02-20 Created: 2018-02-20 Last updated: 2018-02-20Bibliographically approved

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