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The impact of cognitive training in substance use disorder: the effect of working memory training on impulse control in methamphetamine users
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology. UCT Department of Psychiatry and Mental Health Groote Schuur Hospital Cape Town South Africa.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
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2017 (English)In: Psychopharmacology, ISSN 0033-3158, E-ISSN 1432-2072, Vol. 234, no 12, p. 1911-1921Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Impulsivity is a vulnerability trait for poor self-regulation in substance use disorder (SUD). Working memory (WM) training improves impulsivity and self-regulation in psychiatric disorders. Here we test WM training in methamphetamine use disorder (MUD).

METHODS: There are 15 MUD patients receiving inpatient treatment as usual (TAU) and 20 who additionally completed WM cognitive training (CT) and 25 healthy controls (HC). MANCOVA repeated measures analyses examined changes in impulsivity and self-regulation at baseline and after 4 weeks.

RESULTS:  = 0.3523, p < 0.05). Compared to follow-up TAU, follow-up CT group had higher self-reported mood scores (t = 2.784, p = 0.01) and higher compared to CT baseline (t = 2.386, p = 0.036). Feelings of self-control were higher in CT than TAU at follow-up (t = 2.736, p = 0.012) and also compared to CT baseline (t = 3.390, p = 0.006), lack of planning significantly improved in CT between baseline and follow-up (t = 2.219, p = 0.048), as did total impulsivity scores (t = 2.085, p = 0.048). Measures of self-regulation were improved in the CT group compared to TAU at follow-up, in total score (t = 2.442, p = 0.038), receiving score (t = 2.314, p = 0.029) and searching score (t = 2.362, p = 0.027). Implementing self-regulation was higher in the CT group compared to TAU (t = 2.373, p = 0.026).

CONCLUSIONS: WM training may improve control of impulsivity and self-regulation in people with MUD.

Place, publisher, year, edition, pages
2017. Vol. 234, no 12, p. 1911-1921
Keywords [en]
Impulsivity, Methamphetamine, Self-regulation, Working memory
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-342263DOI: 10.1007/s00213-017-4597-6ISI: 000402460100011PubMedID: 28324119OAI: oai:DiVA.org:uu-342263DiVA, id: diva2:1183920
Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-02-20Bibliographically approved

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