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Innovative intraoral cooling device better tolerated and equally effective as ice cooling
Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
Univ West, Trollhättan, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
2017 (English)In: Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, E-ISSN 1432-0843, Vol. 80, no 5, p. 965-972Article in journal (Refereed) Published
Abstract [en]

Most of the patients who receive myeloablative therapy prior to stem cell transplantation develop oral mucositis (OM). This adverse reaction manifests as oral mucosal erythema and ulcerations and may require high doses of morphine for pain alleviation. OM may also interfere with food intake and result in weight loss, a need for parenteral nutrition, and impaired quality of life. To date, there have been very few studies of evidence-based interventions for the prevention of OM. Cryotherapy, using ice chips, has been shown to reduce in an efficient manner the severity and extent of OM, although clinical applications are still limited due to several shortcomings, such as adverse tooth sensations, problems with infectious organisms in the water, nausea, and uneven cooling of the oral mucosa. The present proof-of-concept study was conducted to compare the tolerability, temperature reduction, and cooling distribution profiles of an intra-oral cooling device and ice chips in healthy volunteers who did not receive myeloablative treatment, and therefore, did not experience the symptoms of OM. Twenty healthy volunteers used the cooling device and ice chips for a maximum of 60 min each, using a cross-over design. The baseline and final temperatures were measured at eight intra-oral locations using an infra-red thermographic camera. The thermographic images were analysed using two digital software packages. A questionnaire was used to assess the tolerability levels of the two interventions. The intra-oral cooling device was significantly better tolerated than the ice-chips (p = 0.0118). The two interventions were equally effective regarding temperature reduction and cooling distribution. The intra-oral cooling device shows superior tolerability in healthy volunteers. Furthermore, this study shows that temperature reduction and cooling distribution are achieved equally well using either method.

Place, publisher, year, edition, pages
2017. Vol. 80, no 5, p. 965-972
Keywords [en]
Cryotherapy, Tolerability, Healthy volunteers, Intra-oral cooling device, Oral mucositis, Myeloablative therapy
National Category
Cancer and Oncology Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-341946DOI: 10.1007/s00280-017-3434-2ISI: 000414762300009PubMedID: 28975429OAI: oai:DiVA.org:uu-341946DiVA, id: diva2:1183296
Available from: 2018-02-16 Created: 2018-02-16 Last updated: 2018-02-16Bibliographically approved

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