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Serum miRNA levels are related to glucose homeostasis and islet autoantibodies in children with high risk for type 1 diabetes
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
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2018 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 1, article id e0191067Article in journal (Refereed) Published
Abstract [en]

Micro RNAs (miRNAs) are promising disease biomarkers due to their high stability. Their expression in serum is altered in type 1 diabetes, but whether deviations exist in individuals with high risk for type 1 diabetes remains unexplored. We therefore assessed serum miRNAs in high-risk individuals (n = 21) positive for multiple islet autoantibodies, age-matched healthy children (n = 17) and recent-onset type 1 diabetes patients (n = 8), using Serum/Plasma Focus microRNA PCR Panels from Exiqon. The miRNA levels in the high-risk group were similar to healthy controls, and no specific miRNA profile was identified for the high-risk group. However, serum miRNAs appeared to reflect glycemic status and ongoing islet auto-immunity in high-risk individuals, since several miRNAs were associated to glucose homeostasis and autoantibody titers. High-risk individuals progressing to clinical disease after the sampling could not be clearly distinguished from non-progressors, while miRNA expression in the type 1 diabetes group deviated significantly from high-risk individuals and healthy controls, perhaps explained by major metabolic disturbances around the time of diagnosis.

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PUBLIC LIBRARY SCIENCE , 2018. Vol. 13, no 1, article id e0191067
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Endocrinology and Diabetes
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URN: urn:nbn:se:liu:diva-145142DOI: 10.1371/journal.pone.0191067ISI: 000422749500025PubMedID: 29346396OAI: oai:DiVA.org:liu-145142DiVA, id: diva2:1182445
Note

Funding Agencies|Swedish Child Diabetes Foundation (Barndiabetesfonden); Swedish Research Council (Vetenskapsradet); Medical Research Council of Southeast Sweden (Forskningsradet i sydostra sverige, FORSS); Novo Nordisk Foundation; ALF/County Council of Ostergotland

Available from: 2018-02-13 Created: 2018-02-13 Last updated: 2018-03-10

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Åkerman, LindaCasas, RosauraLudvigsson, JohnnyTavira Iglesias, BeatrizSkoglund, Camilla
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Division of Children's and Women's healthFaculty of Medicine and Health SciencesDepartment of Paediatrics in LinköpingDivision of Drug Research
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