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Regulatory T cells characterized by low Id3 expression are highly suppressive and accumulate during chronic infection
Univ Freiburg, Germany; Fac Biol, Germany.
Univ Freiburg, Germany; Fac Biol, Germany.
Univ Freiburg, Germany; Fac Biol, Germany.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
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2017 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 8, no 61, p. 102835-102851Article in journal (Refereed) Published
Abstract [en]

Foxp3(+) regulatory T (Treg) cells are broadly divided into naive-like and activated Treg cells, however recent studies suggest further Treg cell heterogeneity. Treg cells contribute to impaired T cell responses in chronic infections, but the role of specific Treg cell subpopulations in viral infections is not well defined. Here, we report that activated Treg cells are separated into two transcriptionally distinct subpopulations characterized by low or high expression of the transcriptional regulator Id3. Id3(lo) Treg cells are a highly suppressive Treg cell subpopulation, expressing elevated levels of immunomodulatory molecules and are capable of broadly targeting T cell responses. Viral infection and interleukin-2 promote the differentiation of Id3(hi) into Id3(lo) Treg cells and during chronic infection Id3(lo) Treg cells are the predominant Treg cell population. Thus, our report provides a framework, in which different activated Treg cell subpopulations specifically affect immune responses, possibly contributing to T cell dysfunction in chronic infections.

Place, publisher, year, edition, pages
IMPACT JOURNALS LLC , 2017. Vol. 8, no 61, p. 102835-102851
Keywords [en]
Treg cells; chronic infection; transcription; Id proteins; immunology
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-145165DOI: 10.18632/oncotarget.22159ISI: 000419562500010PubMedID: 29262527OAI: oai:DiVA.org:liu-145165DiVA, id: diva2:1182248
Note

Funding Agencies|International Graduate Academy fellowship; Fill-in-the-gap stipend; German Research Foundation [DFG SCHA 1442/5-1, DFG SCHA 1442/6-1, DFG SFB1160-IMPATH TP2]; Federal Ministry of Education and Research [BMBF 01EO1303]; European Commission [FP7 PIRG08-GA-2010-276906]; Muller-Fahnenberg Stiftung; German Research Foundation (DFG) [SFB1160-IMPATH TP5]

Available from: 2018-02-12 Created: 2018-02-12 Last updated: 2018-03-09

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