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Electric Field Comparison between Microelectrode Recording and Deep Brain Stimulation Systems: A Simulation Study
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-6896-1452
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. University of Applied Sciences and Arts Northwestern Switzerland FHNW, 4132 Muttenz, Switzerland.
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-0012-7867
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2018 (English)In: Brain Sciences, ISSN 2076-3425, E-ISSN 2076-3425, Vol. 8, no 2Article in journal (Refereed) Published
Abstract [en]

The success of deep brain stimulation (DBS) relies primarily on the localization of the implanted electrode. Its final position can be chosen based on the results of intraoperative microelectrode recording (MER) and stimulation tests. The optimal position often differs from the final one selected for chronic stimulation with the DBS electrode. The aim of the study was to investigate, using finite element method (FEM) modeling and simulations, whether lead design, electrical setup, and operating modes induce differences in electric field (EF) distribution and in consequence, the clinical outcome. Finite element models of a MER system and a chronic DBS lead were developed. Simulations of the EF were performed for homogenous and patient-specific brain models to evaluate the influence of grounding (guide tube vs. stimulator case), parallel MER leads, and non-active DBS contacts. Results showed that the EF is deformed depending on the distance between the guide tube and stimulating contact. Several parallel MER leads and the presence of the non-active DBS contacts influence the EF distribution. The DBS EF volume can cover the intraoperatively produced EF, but can also extend to other anatomical areas. In conclusion, EF deformations between stimulation tests and DBS should be taken into consideration as they can alter the clinical outcome

Place, publisher, year, edition, pages
MDPI , 2018. Vol. 8, no 2
Keyword [en]
microelectrode recording (MER); finite element method (FEM); deep brain stimulation (DBS); brain model; Dice coefficient; patient-specific
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-145112DOI: 10.3390/brainsci8020028OAI: oai:DiVA.org:liu-145112DiVA: diva2:1182170
Available from: 2018-02-12 Created: 2018-02-12 Last updated: 2018-02-21

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Alonso, FabiolaVogel, DorianJohansson, JohannesWårdell, KarinHemm, Simone
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