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Large-scale suppression of recombination predates genomic rearrangements in Neurospora tetrasperma
South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England..
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2017 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, article id 1140Article in journal (Refereed) Published
Abstract [en]

A common feature of eukaryote genomes is large chromosomal regions where recombination is absent or strongly reduced, but the factors that cause this reduction are not well understood. Genomic rearrangements have often been implicated, but they may also be a consequence of recombination suppression rather than a cause. In this study, we generate eight high-quality genomic data sets of the filamentous ascomycete Neurospora tetrasperma, a fungus that lacks recombination over most of its largest chromosome. The genomes surprisingly reveal collinearity of the non-recombining regions and although large inversions are enriched in these regions, we conclude these inversions to be derived and not the cause of the suppression. To our knowledge, this is the first time that non-recombining, genic regions as large as 86% of a full chromosome (or 8 Mbp), are shown to be collinear. These findings are of significant interest for our understanding of the evolution of sex chromosomes and other supergene complexes.

Place, publisher, year, edition, pages
2017. Vol. 8, article id 1140
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Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-341371DOI: 10.1038/s41467-017-01317-6ISI: 000413830800002PubMedID: 29074958OAI: oai:DiVA.org:uu-341371DiVA, id: diva2:1181199
Funder
EU, European Research CouncilSwedish Research CouncilScience for Life Laboratory - a national resource center for high-throughput molecular bioscienceAvailable from: 2018-02-08 Created: 2018-02-08 Last updated: 2018-02-26Bibliographically approved

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