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Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology
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2017 (English)In: Open Forum Infectious Diseases, ISSN 2328-8957, Vol. 4, no 4, article id ofx229Article in journal (Refereed) Published
Abstract [en]

The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage.

Place, publisher, year, edition, pages
Oxford University Press, 2017. Vol. 4, no 4, article id ofx229
Keywords [en]
case-fatality rate, complement, hantavirus, Puumala virus, vascular leakage
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:umu:diva-144431DOI: 10.1093/ofid/ofx229ISI: 000419560500051PubMedID: 29255728OAI: oai:DiVA.org:umu-144431DiVA, id: diva2:1179817
Available from: 2018-02-02 Created: 2018-02-02 Last updated: 2018-06-09Bibliographically approved

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