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Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Cardiology Department, Letterkenny University Hospital, Letterkenny, Co. Donegal, Ireland.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Umeå University, Faculty of Medicine, Department of Odontology. (Aa-gruppen)ORCID iD: 0000-0002-8069-8263
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
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2018 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 19, no 1, article id 260Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Coronary artery ectasia (CAE) is a rare disorder commonly associated with additional features of atherosclerosis. In the present study, we aimed to examine the systemic immune-inflammatory response that might associate CAE.

METHODS: Plasma samples were obtained from 16 patients with coronary artery ectasia (mean age 64.9 ± 7.3 years, 6 female), 69 patients with coronary artery disease (CAD) and angiographic evidence for atherosclerosis (age 64.5 ± 8.7 years, 41 female), and 140 controls (mean age 58.6 ± 4.1 years, 40 female) with normal coronary arteries. Samples were analyzed at Umeå University Biochemistry Laboratory, Sweden, using the V-PLEX Pro-Inflammatory Panel 1 (human) Kit. Statistically significant differences (p < 0.05) between patient groups and controls were determined using Mann-Whitney U-tests.

RESULTS: The CAE patients had significantly higher plasma levels of INF-γ, TNF-α, IL-1β, and IL-8 (p = 0.007, 0.01, 0.001, and 0.002, respectively), and lower levels of IL-2 and IL-4 (p < 0.001 for both) compared to CAD patients and controls. The plasma levels of IL-10, IL-12p, and IL-13 were not different between the three groups. None of these markers could differentiate between patients with pure (n = 6) and mixed with minimal atherosclerosis (n = 10) CAE.

CONCLUSIONS: These results indicate an enhanced systemic pro-inflammatory response in CAE. The profile of this response indicates activation of macrophages through a pathway and trigger different from those of atherosclerosis immune inflammatory response.

Place, publisher, year, edition, pages
Basel, Switzerland: MDPI , 2018. Vol. 19, no 1, article id 260
Keywords [en]
atherosclerosis, coronary artery disease, coronary artery ectasia, cytokines, immune inflammatory response, macrophage activation
National Category
Cardiac and Cardiovascular Systems
Research subject
Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-144041DOI: 10.3390/ijms19010260ISI: 000424407200254PubMedID: 29337902OAI: oai:DiVA.org:umu-144041DiVA, id: diva2:1177844
Funder
Swedish Heart Lung FoundationAvailable from: 2018-01-26 Created: 2018-01-26 Last updated: 2018-06-09Bibliographically approved

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Boles, UsamaJohansson, AndersWiklund, UrbanHenein, Michael Y.
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