Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Early dietary effects of arachidonic acid on gene expression linked to  immune response and metabolism in rural and urban Great Tit (Parus Major) nestlings
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre. Molecular Ecology and Evolution Lab , Lund University.
2017 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

This study was conducted to test the silver spoon hypothesis that earlylife nutritional conditions impact development, performance and fitness of the birdsgreat tit (Parus major) nestlings. We investigated whether fatty acid affects immunityand metabolism during the altricial period by examining the expressions of geneTLR4 (immunity related) and COX 2 (metabolism related) against a dietarymanipulation on great tit nestlings in urban vs. rural environments. The resultssuggested that arachidonic acid had no significant effect on TLR4 expression, but atendency to induce immune response, regardless of urban or rural conditions. Thestrength of immune response was however negatively correlated with laying date. Theurban great tit nestlings had a higher COX 2 gene expression than rural ones, andarachidonic acid suppressed COX 2.Thus no strong support to the hypothesis was found for the studied great titpopulations. It showed, however, i) there is a tendency of increasing immune responsewith extra fatty acid in the diet, and ii) arachidonic acid suppress metabolism. Fattyacid involved in a multiple physiological processes and this complex need to beelaborated in future studies.

Place, publisher, year, edition, pages
2017. , p. 27
Keywords [en]
gene expression, dietary manipulation, arachidonic acid
National Category
Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-339547OAI: oai:DiVA.org:uu-339547DiVA, id: diva2:1176040
Supervisors
Examiners
Available from: 2018-01-26 Created: 2018-01-19 Last updated: 2018-01-26Bibliographically approved

Open Access in DiVA

fulltext(1997 kB)36 downloads