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Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor
Örebro University, School of Medical Sciences. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.ORCID iD: 0000-0002-2856-9165
Florida Hospital Orlando, Neuroscience Research Institute, Orlando FL, United States.
Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Florida Hospital Orlando, Neuroscience Research Institute, Orlando FL, United States.
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2018 (English)In: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 11, article id 747Article in journal (Refereed) Published
Abstract [en]

Progression to AD is preceded by elevated levels of 2,4-dihydroxybutanoic acid (2,4-DHB), implicating hypoxia in early pathogenesis. Since hypoxia may play a role in multiple CNS disorders, we investigated serummetabolite profiles across three disorders, AD, Normal Pressure Hydrocephalus (NPH) and brain tumors (BT). Blood samples were collected from27 NPH and 20 BT patients. The profiles of 21metabolites were examined. Additionally, data from 37 AD patients and 46 controls from a previous study were analyzed together with the newly acquired data. No differences in 2,4-DHB were found across AD, NPH and BT samples. In the BT group, the fatty acids were increased as compared to HC and NPH groups, while the ketone body 3-hydroxybutyrate was increased as compared to AD. Glutamic acid was increased in AD as compared to the HC group. In the AD group, 3-hydroxybutyrate tended to be decreased with respect to all other groups (mean values −30% or more), but the differences were not statistically significant. Serine was increased in NPH as compared to BT. In conclusion, AD, NPH and BT have different metabolic profiles. This preliminary study may help in identifying the blood based markers that are specific to these three CNS diseases.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2018. Vol. 11, article id 747
Keywords [en]
Alzheimer’s disease, brain tumor, hypoxia, metabolomics, normal pressure hydrocephalus
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:oru:diva-64339DOI: 10.3389/fnins.2017.00747ISI: 000419589000001Scopus ID: 2-s2.0-85040451494OAI: oai:DiVA.org:oru-64339DiVA, id: diva2:1175067
Note

Funding Agency:

Karen L. Wrenn Estate under the Florida Hospital Foundation

Available from: 2018-01-17 Created: 2018-01-17 Last updated: 2018-09-07Bibliographically approved

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