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Spatial detection of fetal marker genes expressed at low level in adult human heart tissue
KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, Stockholm, Sweden..
KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, Stockholm, Sweden..
Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden..
KTH Royal Inst Technol, Div Gene Technol, Sci Life Lab, Stockholm, Sweden..
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2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 12941Article in journal (Refereed) Published
Abstract [en]

Heart failure is a major health problem linked to poor quality of life and high mortality rates. Hence, novel biomarkers, such as fetal marker genes with low expression levels, could potentially differentiate disease states in order to improve therapy. In many studies on heart failure, cardiac biopsies have been analyzed as uniform pieces of tissue with bulk techniques, but this homogenization approach can mask medically relevant phenotypes occurring only in isolated parts of the tissue. This study examines such spatial variations within and between regions of cardiac biopsies. In contrast to standard RNA sequencing, this approach provides a spatially resolved transcriptome- and tissue-wide perspective of the adult human heart, and enables detection of fetal marker genes expressed by minor subpopulations of cells within the tissue. Analysis of patients with heart failure, with preserved ejection fraction, demonstrated spatially divergent expression of fetal genes in cardiac biopsies.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 7, article id 12941
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Basic Medicine
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URN: urn:nbn:se:uu:diva-338515DOI: 10.1038/s41598-017-13462-5ISI: 000412781300009PubMedID: 29021611OAI: oai:DiVA.org:uu-338515DiVA, id: diva2:1173885
Funder
AstraZenecaKnut and Alice Wallenberg FoundationSwedish Foundation for Strategic Research Swedish Research CouncilScience for Life Laboratory - a national resource center for high-throughput molecular bioscienceAvailable from: 2018-01-15 Created: 2018-01-15 Last updated: 2018-01-15Bibliographically approved

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