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Prediction of co-expression genes and integrative analysis of gene microarray and proteomics profile of Keshan disease
School of Public Health, Health Science Center of Xi'an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi, China.
Department of Cardiology, the Second Affiliated Hospital, Health Science Center of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ordance Industrial Hygiene Research Institute, Xi'an, Shaanxi, China.
School of Public Health, Health Science Center of Xi'an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi, China.
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 231Article in journal (Refereed) Published
Abstract [en]

Keshan disease (KD) is a kind of endemic cardiomyopathy which has a high mortality. However, molecular mechanism in the pathogenesis of KD remains poorly understood. Serum samples were collected from 112 KD patients and 112 normal controls. Gene microarray was used to screen differently expressed genes. Genevestigator was applied to forecast co-expression genes of significant gene. iTRAQ proteomics analysis was used to verify significant genes and their co-expression genes. GO, COG, IPA and STRING were applied to undertake function categorization, pathway and network analysis separately. We identified 32 differentially expressed genes; IDH2, FEM1A, SSPB1 and their respective 30 co-expression genes; 68 differential proteins in KD. Significant proteins were categorized into 23 biological processes, 16 molecular functions, 16 cellular components, 15 function classes, 13 KD pathways and 1 network. IDH2, FEM1A, SSBP1, CALR, NDUFS2, IDH3A, GAPDH, TCA Cycle II (Eukaryotic) pathway and NADP repair pathway may play important roles in the pathogenesis of KD.

Place, publisher, year, edition, pages
London: Nature Publishing Group, 2018. Vol. 8, article id 231
Keyword [en]
Keshan disease, cardiomyopathy, protoemics, gene array, integrative analysis
National Category
Cardiac and Cardiovascular Systems Cell and Molecular Biology
Research subject
Cardiology; Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-143903DOI: 10.1038/s41598-017-18599-xISI: 000419668400005PubMedID: 29321553OAI: oai:DiVA.org:umu-143903DiVA, id: diva2:1173772
Available from: 2018-01-14 Created: 2018-01-14 Last updated: 2018-03-07Bibliographically approved

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