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Levels of beta-trace protein in optic disc pit with macular detachment
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry. Faculty of Medicine and Health, Department of Biomedicine, Örebro University, Örebro, Sweden.
2017 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 95, no 8, p. 815-819Article in journal (Refereed) Published
Abstract [en]

Background: To report beta-trace protein (bTP) levels in the subretinal fluid (SRF) of four patients with a macular detachment associated with optic disc pit (ODP).

Methods: Four patients with a serous retinal detachment involving the macula was operated by pars plana vitrectomy (PPV) with C2F6 gas tamponade and peeling of internal limiting membrane (ILM). Patients with a follow-up period exceeding one year postoperatively were included in the study. The SRF was drained using a fine cannula without laser photocoagulation, and the samples were analysed using particle-enhancing nephelometry. The levels of bTP were compared to 20 routine cerebrospinal fluid (CSF) samples.

Results: In four of the five samples from SRF had relatively low bTP levels, with a mean concentration of 6.6 mg/l (range 2.0 to 23.1 mg/l) compared to 16.0 mg/ l (range 6.3-26.8 mg/l) in CSF. The only SRF sample within the range corresponding to normal CSF was the first sample from patient 4, and the analysis of the renewed aspirate during the second operation was 2.8 mg/l. Postoperatively, the regression of SRF was slow, but regression of SRF in the foveal region took place in all cases; however, visual acuity (VA) was improved in only half of the patients.

Conclusion: The results from the analysed SRF regarding bTP concentration in these patients indicate that the SRF in ODP is not identical to CSF, as the concentrations of bTP differ.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017. Vol. 95, no 8, p. 815-819
Keyword [en]
beta trace, beta-trace protein, optic disc pit
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:umu:diva-143571DOI: 10.1111/aos.13527ISI: 000417645900036PubMedID: 28926186OAI: oai:DiVA.org:umu-143571DiVA, id: diva2:1170678
Available from: 2018-01-04 Created: 2018-01-04 Last updated: 2018-01-24Bibliographically approved

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