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Hierarchical recruitment of Polycomb complexes revisited
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
2017 (English)In: Nucleus, ISSN 1949-1034, E-ISSN 1949-1042, Vol. 8, no 5, p. 496-505Article in journal (Refereed) Published
Abstract [en]

Polycomb Group (PcG) proteins epigenetically repress key developmental genes and thereby control alternative cell fates. PcG proteins act as complexes that can modify histones and these histone modifications play a role in transmitting the memory of the repressed state as cells divide. Here we consider mainstream models that link histone modifications to hierarchical recruitment of PcG complexes and compare them to results of a direct test of interdependence between PcG complexes for recruitment to Drosophila genes. The direct test indicates that PcG complexes do not rely on histone modifications to recognize their target genes but use them to stabilize the interactions within large chromatin domains. It also shows that multiple strategies are used to coordinate the targeting of PcG complexes to different genes, which may make the repression of these genes more or less robust.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2017. Vol. 8, no 5, p. 496-505
Keywords [en]
Drosophila, epigenetics, Polycomb, Polycomb targeting, Polycomb Response Elements
National Category
Developmental Biology Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-143565DOI: 10.1080/19491034.2017.1363136ISI: 000418054400008PubMedID: 28910569OAI: oai:DiVA.org:umu-143565DiVA, id: diva2:1170548
Available from: 2018-01-03 Created: 2018-01-03 Last updated: 2018-06-09Bibliographically approved

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Dorafshan, EshaghKahn, Tatyana G.Schwartz, Yuri B.
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