Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The effect of malnutrition on saliva composition and caries development
Umeå University, Faculty of Medicine, Department of Odontology.
1986 (English)Doctoral thesis, monograph (Other academic)
Abstract [en]

Starvation and protein deficiency increase susceptibility to infec­tions in general and affect the function of various types of cells individually. Saliva contains substances which offer protection to the oral tissues. Its composition and secretion rate may be important in preventing the development of disease, e.g. dental caries. The aim of the present study was to evaluate the effects of starvation and protein deficiency on the secretion and composition of saliva and the effects possibly induced on dental caries.

The following results were found.

Short-term starvation on a liquid diet reduced the secretion rate and changed the composition of saliva in healthy humans. Chewing during starvation while it did not restore secretion rate, did partially restore the composition.

Total protein concentration was not greatly affected by gross mal­nutrition or protein deficiency. A more pronounced effect was observed on individual biologically active proteins. The salivary glands seem not to be prime targets for malnutrition but the rate of biosynthesis of a bacteria aggregating glycoprotein and the activity of salivary peroxidase were significantly reduced by a long-term protein deficien­cy and gross malnutrition respectively in the rat. In humans, short­term starvation on a liquid diet caused an impaired glycosylation of sialic acid to the protein and decreased lysozyme activity. Sialylation was partially restored by chewing.

In the rat the establishment of a cariogenic microorganism, S. cricetus (S. mutans) strain E 49 serotype a, was facilitated by protein deficiency.

Starvation in both man and the rat produced evident clinical effects. The rate of plaque formation was increased in man and in the rat there was significant increase in caries development induced by a standardi­zed cariogenic challenge.

This study shows that nutrition is important for the secretion of saliva and that starvation and protein deficiency increase the cario- genicity of sucrose.

Place, publisher, year, edition, pages
Umeå: Umeå universitet , 1986. , p. 116
Series
Umeå University odontological dissertations, ISSN 0345-7532 ; 25
Keywords [en]
starvation, protein-deficiency, antibacterial proteins, saliva, caries, infection
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-143485OAI: oai:DiVA.org:umu-143485DiVA, id: diva2:1170242
Projects
digitalisering@umu
Note

S. 1-49: sammanfattning, s. 51-116: 5 uppsatser

Available from: 2018-01-02 Created: 2018-01-02 Last updated: 2018-01-02Bibliographically approved

Open Access in DiVA

fulltext(2409 kB)11 downloads
File information
File name FULLTEXT01.pdfFile size 2409 kBChecksum SHA-512
1cb7d34dbce0b6f8d7a1e6ad3a434cfd998ba77f9800548d755399a428cf55b821776c9786553a7549c91de04345f065b300f9301d47398004458b2285b5171e
Type fulltextMimetype application/pdf

By organisation
Department of Odontology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 11 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 30 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf