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The integrative clinical impact of tumor-infiltrating T lymphocytes and NK cells in relation to B lymphocyte and plasma cell density in esophageal and gastric adenocarcinoma
Lund Univ, Dept Clin Sci Lund, Oncol & Pathol, Lund, Sweden..
Lund Univ, Dept Clin Sci Lund, Oncol & Pathol, Lund, Sweden..
Lund Univ, Dept Clin Sci Lund, Oncol & Pathol, Lund, Sweden..
Lund Univ, Dept Clin Sci Lund, Oncol & Pathol, Lund, Sweden..
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2017 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 8, no 42, p. 72108-72126Article in journal (Refereed) Published
Abstract [en]

Background: Several studies have demonstrated a prognostic impact of tumor-infiltrating T lymphocytes and natural killer (NK) cells in esophageal and gastric adenocarcinoma, but whether these associations differ by the density of tumor-infiltrating immune cells of the B cell lineage remains largely unknown. Results: High infiltration of any T and NK lymphocytes investigated was in general associated with a favorable prognosis, but the strongest beneficial prognostic impact was seen in combination with high B lymphocyte infiltration. These findings were most evident in gastric cancer, where significant interactions in relation to OS were observed for CD3(+), CD8(+) and FoxP3(+) with CD20(+) cells (p(interaction) = 0.012, 0.009 and 0.007, respectively) and for FoxP3(+) with IGKC(+) cells (p(interaction) = 0.034). In esophageal tumors, there was only a significant interaction for CD3(+) and CD20 (+) cells (p(interaction) = 0.028). Methods: Immunohistochemistry and automated image analysis was applied to assess the density of T lymphocytes (CD3(+), CD8(+), FoxP3(+)) and NK cells (NKp46(+)) in chemoradiotherapy-naive tumors from a consecutive cohort of 174 patients with resected esophageal or gastric adenocarcinoma. The density of B lymphocytes (CD20(+)) and plasma cells (IGKC(+)) had been assessed previously. Kaplan-Meier analysis and Cox proportional hazard's modelling was applied to examine the impact of the investigated markers on time to recurrence (TTR) and overall survival (OS). Conclusions: These data support that the antitumoral effects of tumor-infiltrating T lymphocytes in esophageal and gastric adenocarcinoma may be largely dependent on a functional interplay between T and B lymphocytes or plasma cells.

Place, publisher, year, edition, pages
IMPACT JOURNALS LLC , 2017. Vol. 8, no 42, p. 72108-72126
Keywords [en]
T lymphocytes, B lymphocytes, esophageal cancer, gastric cancer, prognosis
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-336477DOI: 10.18632/oncotarget.19437ISI: 000411509400060PubMedID: 29069772OAI: oai:DiVA.org:uu-336477DiVA, id: diva2:1168363
Available from: 2017-12-20 Created: 2017-12-20 Last updated: 2018-02-01Bibliographically approved

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