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Labor Induction with Orally Administrated Misoprostol: A Retrospective Cohort Study
Karolinska Institutet, Department of Clinical Science and Education, Women’s Clinic, Södersjukhuset.
Karolinska Institutet, Department of Clinical Science and Education, Women’s Clinic, Södersjukhuset.
Karolinska Institutet, Department of Clinical Science and Education, Women’s Clinic, Södersjukhuset.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
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2017 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, article id 6840592Article in journal (Refereed) Published
Abstract [en]

Introduction. One great challenge in obstetric care is labor inductions. Misoprostol has advantages in being cheap and stable at room temperature and available in resource-poor settings.

Material and Methods. Retrospective cohort study of 4002 singleton pregnancies with a gestational age >= 34w at Sodersjukhuset, Stockholm, during 2009-2010 and 2012-2013. Previously usedmethods of labor induction were compared with misoprostol given as a solution to drink, every second hour. Main outcome is as follows: Cesarean Section (CS) rate, acid-base status in cord blood, Apgar score < 7,5 ', active time of labor, and blood loss > 1500 ml (PPH).

Results. The proportion of CS decreased from 26% to 17% when orally given solution of misoprostol was introduced at the clinic (p < 0.001). No significant difference in the frequency of low Apgar score (p = 0.3), low aPh in cord blood (p = 0.1), or PPH (p = 0.4) between the differentmethods of induction was studied. After adjustment for different risk factor for CS the only method of induction which was associated with CS was dinoproston** (Propess (R)) (aor = 2.9 (1.6-5.2)).

Conclusion. Induction of labor with misoprostol, given as an oral solution to drink every second hour, gives a low rate of CS, without affecting maternal or fetal outcome.

Place, publisher, year, edition, pages
2017. article id 6840592
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Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
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URN: urn:nbn:se:uu:diva-335766DOI: 10.1155/2017/6840592ISI: 000411050600001OAI: oai:DiVA.org:uu-335766DiVA, id: diva2:1166464
Available from: 2017-12-15 Created: 2017-12-15 Last updated: 2017-12-15Bibliographically approved

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Åkerud, HelenaDarj, Elisabeth
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Medicinsk genetik och genomikDepartment of Immunology, Genetics and Pathology
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