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NANOCI-Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons
Univ Bern, Inselspital, Univ Dept ORL Head & Neck Surg, Bern, Switzerland.;Univ Bern, Dept Clin Res, Bern, Switzerland.;Univ Hosp Geneva, Dept Clin Neurosci, Serv ORL & HNS, HUG, Geneva, Switzerland..
Univ Bern, Inselspital, Univ Dept ORL Head & Neck Surg, Bern, Switzerland.;Univ Bern, Dept Clin Res, Bern, Switzerland..
Univ Bern, Inselspital, Univ Dept ORL Head & Neck Surg, Bern, Switzerland.;Univ Bern, Dept Clin Res, Bern, Switzerland..
Univ Tubingen, Dept Otorhinolaryngol Head & Neck Surg, Tubingen, Germany..
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2017 (English)In: Otology and Neurotology, ISSN 1531-7129, E-ISSN 1537-4505, Vol. 38, no 8, p. E224-E231Article in journal (Refereed) Published
Abstract [en]

Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the tremendous success of these devices, some limitations remain. The bottleneck for optimal electrical stimulation with CI is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through 1) low frequency resolution, hence suboptimal sound quality and 2), large stimulation currents, hence high energy consumption (responsible for significant battery costs and for impeding the development of fully implantable systems). A recently completed, multinational and interdisciplinary project called NANOCI aimed at overcoming current limitations by creating a gapless interface between auditory nerve fibers and the cochlear implant electrode array. This ambitious goal was achieved in vivo by neurotrophin-induced attraction of neurites through an intra-cochlear gel-nanomatrix onto a modified nanoCI electrode array located in the scala tympani of deafened guinea pigs. Functionally, the gapless interface led to lower stimulation thresholds and a larger dynamic range in vivo, and to reduced stimulation energy requirement (up to fivefold) in an in vitro model using auditory neurons cultured on multi-electrode arrays. In conclusion, the NANOCI project yielded proof of concept that a gapless interface between auditory neurons and cochlear implant electrode arrays is feasible. These findings may be of relevance for the development of future CI systems with better sound quality and performance and lower energy consumption. The present overview/review paper summarizes the NANOCI project history and highlights achievements of the individual work packages.

Place, publisher, year, edition, pages
2017. Vol. 38, no 8, p. E224-E231
Keyword [en]
Auditory nerve regeneration, BDNF, Cochlear implant, Gapless interface, Guinea pig, Hearing loss, Hydrogel, Multi-electrode array, Neuron-electrode interface
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:uu:diva-335874DOI: 10.1097/MAO.0000000000001439ISI: 000411032100003PubMedID: 28806330OAI: oai:DiVA.org:uu-335874DiVA, id: diva2:1166091
Conference
14th International Conference on Cochlear Implants and other Implantable Auditory Technologies, MAY 11-14, 2016, Toronto, CANADA
Funder
EU, European Research Council, 281056
Available from: 2017-12-14 Created: 2017-12-14 Last updated: 2017-12-14Bibliographically approved

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