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Assessment of MRI contrast agent concentration by quantitative susceptibility mapping (QSM): application to estimation of cerebral blood volume during steady state
Lund University, Sweden.
Lund University, Sweden; Johns Hopkins School Med, MD USA.
Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. Lund University, Sweden.
Lund University, Sweden; Lund University, Sweden.
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2017 (English)In: Magnetic Resonance Materials in Physics, Biology and Medicine, ISSN 0968-5243, E-ISSN 1352-8661, Vol. 30, no 6, p. 555-566Article in journal (Refereed) Published
Abstract [en]

One major issue in dynamic susceptibility contrast MRI (DSC-MRI) is to accurately determine contrast agent (CA) concentration, since T2* relaxivity in vivo is generally unknown and varies between blood and tissue. In this study, quantitative susceptibility mapping (QSM) was used for quantification of CA concentration. A DSC-MRI protocol, including phase data acquisition, was applied to 20 healthy volunteers in a test-retest study. By selecting a CSF reference region of interest (ROI), the values of all QSM images were shifted to show no CA-induced change in CSF. CA concentration and cerebral blood volume (CBV) were estimated using shifted QSM data. CSF reference ROI optimization was evaluated by investigation of CBV repeatability. The CBV age dependence was analysed and tissue T2* relaxivity was estimated. The best repeatability of CBV, using an optimal CSF reference ROI, showed test-versus-retest correlations of r = 0.81 and r = 0.91 for white and grey matter, respectively. A slight CBV decrease with age was observed, and the estimated in vivo T2* relaxivity was 85 mM(-1)s(-1). Provided that a carefully selected CSF reference ROI is used to shift QSM image values, susceptibility information can be used to estimate concentration of contrast agent and to calculate CBV.

Place, publisher, year, edition, pages
SPRINGER , 2017. Vol. 30, no 6, p. 555-566
Keyword [en]
Cerebrovascular circulation; Cerebral blood volume; Contrast agents; Magnetic resonance imaging; Magnetometry; QSM
National Category
Medical Image Processing
Identifiers
URN: urn:nbn:se:liu:diva-143624DOI: 10.1007/s10334-017-0637-9ISI: 000416258200005PubMedID: 28631203OAI: oai:DiVA.org:liu-143624DiVA, id: diva2:1165586
Note

Funding Agencies|Crafoord Foundation in Lund; Swedish Research Council [2007-6079, 2010-4454, 2011-2971]; Swedish Cancer Society [2012/597]

Available from: 2017-12-13 Created: 2017-12-13 Last updated: 2018-01-05

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