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The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review
University of Basel, Department of Psychiatry (UPK), CH-4012 Basel, Switzerland.
Division of Neuropaediatrics & Developmental Medicine, University Children's Hospital, Basel, Switzerland.
University of Basel, Department of Psychiatry (UPK), CH-4012 Basel, Switzerland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology. Centre de Diagnostic Radiologique de Carouge CDRC, Geneva, Switzerland.; Faculty of Medicine of the University of Geneva, Switzerland.; Department of Neuroradiology, University Hospital Freiburg, Germany.ORCID iD: 0000-0001-7433-0203
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2017 (English)In: Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, E-ISSN 1873-7528, Vol. 80, p. 457-475, article id S0149-7634(17)30138-0Article in journal (Refereed) Published
Abstract [en]

The brain-gut-axis is an interdependent system affecting neural functions and controlling our eating behaviour. In recent decades, neuroimaging techniques have facilitated its investigation. We systematically looked into functional and neurochemical brain imaging studies investigating how key molecules such as ghrelin, glucagon-like peptide-1 (GLP-1), peptide tyrosine-tyrosine (PYY), cholecystokinin (CCK), leptin, glucose and insulin influence the function of brain regions regulating appetite and satiety. Of the 349 studies published before July 2016 identified in the database search, 40 were included (27 on healthy and 13 on obese subjects). Our systematic review suggests that the plasma level of ghrelin, the gut hormone promoting appetite, is positively correlated with activation in the pre-frontal cortex (PFC), amygdala and insula and negatively correlated with activation in subcortical areas such as the hypothalamus. In contrast, the plasma levels of glucose, insulin, leptin, PYY, GLP-1 affect the same brain regions conversely. Our study integrates previous investigations of the gut-brain matrix during food-intake and homeostatic regulation and may be of use for future meta-analyses of brain-gut interactions.

Place, publisher, year, edition, pages
2017. Vol. 80, p. 457-475, article id S0149-7634(17)30138-0
Keywords [en]
Brain, GLP-1, Ghrelin, Glucose, Gut, Insulin, Leptin, PYY, fMRI
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-336184DOI: 10.1016/j.neubiorev.2017.06.013ISI: 000416879800030PubMedID: 28669754OAI: oai:DiVA.org:uu-336184DiVA, id: diva2:1165201
Available from: 2017-12-12 Created: 2017-12-12 Last updated: 2018-03-09Bibliographically approved

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