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Serum biomarkers to predict risk of testicular and penile cancer in AMORIS
Kings Coll London, Div Canc Studies Translat Oncol & Urol Res, London SE1 9RT, England.;Tata Mem Hosp, Dept Palliat Med, Bombay 400012, Maharashtra, India..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Kings Coll London, Div Canc Studies Translat Oncol & Urol Res, London SE1 9RT, England.ORCID iD: 0000-0001-7181-7083
Kings Coll London, Div Canc Studies Translat Oncol & Urol Res, London SE1 9RT, England..ORCID iD: 0000-0002-3241-2945
Karolinska Inst, Inst Environm Med, Unit Epidemiol, SE-17177 Stockholm, Sweden.;AstraZeneca R & D, S-43150 Molndal, Sweden..
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2017 (English)In: ecancermedicalscience, ISSN 1754-6605, E-ISSN 1754-6605, Vol. 11, article id 762Article in journal (Refereed) Published
Abstract [en]

Purpose: To evaluate the association between commonly measured serum biomarkers of inflammation and penile and testicular cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) study.

Materials and methods: A total of 205,717 subjects had baseline measurements of C-reactive protein, albumin, and haptoglobin. The association between quartiles and dichotomised values of inflammatory markers and penile and testicular cancer risk were analysed by using multivariate Cox proportional hazard models.

Results: A total of 125 men were diagnosed with testicular cancer and 50 with penile cancer during a mean follow-up of 20.3 years. No statistically significant trends were seen between serum inflammatory markers and risk of penile cancer, but higher albumin levels increased the risk of testicular cancer [HR for albumin (g/L): 1.10 (95% CI: 1.03-1.18)]. However, this trend was not observed when using medical cut-offs of albumin.

Conclusions: In the present study, we did not find support for an association between commonly used markers of inflammation and risk of testicular or penile cancer. The role of inflammation may be more complicated and require assessment of more specialised measurements of inflammation in future studies.

Place, publisher, year, edition, pages
CANCER INTELLIGENCE LTD , 2017. Vol. 11, article id 762
Keyword [en]
penile cancer, testicular cancer, serum inflammatory markers, albumin, cohort study, survival analysis
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-335709DOI: 10.3332/ecancer.2017.762ISI: 000409369200002PubMedID: 28900475OAI: oai:DiVA.org:uu-335709DiVA, id: diva2:1164797
Funder
Swedish Cancer Society
Available from: 2017-12-12 Created: 2017-12-12 Last updated: 2017-12-12Bibliographically approved

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