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Optical monitoring of cerebral microcirculationin neurointensive care
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. (MINT)
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. (MINT)ORCID iD: 0000-0002-0555-8877
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. (MINT)ORCID iD: 0000-0002-0012-7867
2018 (English)In: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 56, no 7, p. 1201-1210Article in journal (Refereed) Published
Abstract [en]

Continuous optical monitoring of local cerebral microcirculation could benefit neurointensive care patients treated for subarachnoid hemorrhage (SAH). The aim of the study was to evaluate laser Doppler flowmetry (LDF) and diffuse reflectance spectroscopy (DRS) for long-term monitoring of brain microcirculation and oxygen saturation (SO2) in the neurointensive care unit (NICU). A fiber optic probe was designed for intraparenchymal use and connected to LDF and DRS for assessment of the local blood flow (perfusion and tissue reflectance (TLI)) and SO2in the brain. The optically monitored parameters were compared with conventional NICU monitors and Xe-CT. The LDF signals were low with median and 25 to 75% interquartiles of perfusion = 70 (59 to 83) a.u. and TLI = 2.0 (1.0 to 2.4) a.u. and showed correlation with the NICU monitors in terms of heart rate. Median and interquartiles of SO2 were 17.4 (15.7 to 19.8) %. The lack of correlation between local perfusion and cerebral perfusion pressure indicated intact cerebral autoregulation. The systems were capable of monitoring both local perfusion and SO2 with stable signals in the NICU over 4 days. Further clinical studies are required to evaluate the optical systems’ potential for assessing the onset of secondary brain injury.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2018. Vol. 56, no 7, p. 1201-1210
Keywords [en]
Neurointensive care Cerebral blood flow (CBF), Oxygenation Diffuse reflectance spectroscopy (DRS), Laser Doppler flowmetry (LDF), Subarachnoid hemorrhage (SAH)
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-143481DOI: 10.1007/s11517-017-1725-8ISI: 000435970600007PubMedID: 29218511Scopus ID: 2-s2.0-85037327736OAI: oai:DiVA.org:liu-143481DiVA, id: diva2:1164154
Note

Funding agencies:  Swedish Research Council [621-2010-4216, 621-2013-6078]; ALF Grants Region Ostergotland [LIO-599651]

Available from: 2017-12-10 Created: 2017-12-10 Last updated: 2018-07-23Bibliographically approved

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Rejmstad, PeterHaj Hosseini, NedaÅneman, OscarWårdell, Karin
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