Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses
Tech Univ Dresden, Inst Med Informat & Biometry, D-01307 Dresden, Germany..
Heidelberg Univ, Dept Infect Dis, Mol Virol, D-69120 Heidelberg, Germany..
European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Show others and affiliations
2017 (English)In: Cell Host and Microbe, ISSN 1931-3128, E-ISSN 1934-6069, Vol. 22, no 3, p. 387-399,e1-e6Article in journal (Refereed) Published
Abstract [en]

Hepatitis B viruses (HBVs), which are enveloped viruses with reverse-transcribed DNA genomes, constitute the family Hepadnaviridae. An outstanding feature of HBVs is their streamlined genome organization with extensive gene overlap. Remarkably, the similar to 1,100 bp open reading frame (ORF) encoding the envelope proteins is fully nested within the ORF of the viral replicase P. Here, we report the discovery of a diversified family of fish viruses, designated nackednaviruses, which lack the envelope protein gene, but otherwise exhibit key characteristics of HBVs including genome replication via proteinprimed reverse-transcription and utilization of structurally related capsids. Phylogenetic reconstruction indicates that these two virus families separated more than 400 million years ago before the rise of tetrapods. We show that HBVs are of ancient origin, descending from non-enveloped progenitors in fishes. Their envelope protein gene emerged de novo, leading to a major transition in viral lifestyle, followed by co-evolution with their hosts over geologic eras.

Place, publisher, year, edition, pages
2017. Vol. 22, no 3, p. 387-399,e1-e6
National Category
Microbiology
Identifiers
URN: urn:nbn:se:uu:diva-335190DOI: 10.1016/j.chom.2017.07.019ISI: 000410565400018PubMedID: 28867387OAI: oai:DiVA.org:uu-335190DiVA, id: diva2:1163923
Available from: 2017-12-08 Created: 2017-12-08 Last updated: 2017-12-08Bibliographically approved

Open Access in DiVA

fulltext(5236 kB)9 downloads
File information
File name FULLTEXT01.pdfFile size 5236 kBChecksum SHA-512
9077a7339446347221ab4adc811b32e2fa16eb598664337f002bcf00158cce13da57292ef616021c2499db94010847a04a0c969014903a836748910f8386090f
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Suh, Alexander
By organisation
Evolutionary Biology
In the same journal
Cell Host and Microbe
Microbiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 9 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 72 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf