Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Insights into the detection of mutations and epigenetic markers using diamondoid-functionalized sensors
Univ Stuttgart, Inst Computat Phys, Stuttgart, Germany..
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. Univ Fed Fluminense, Dept Fis, ICEx, Volta Redonda, RJ, Brazil..
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
Univ Stuttgart, Inst Computat Phys, Stuttgart, Germany..
2017 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 7, no 68, p. 43064-43072Article in journal (Refereed) Published
Abstract [en]

Nanogaps functionalized with small diamond-like particles, diamondoids, have been shown to effectively distinguish between different DNA nucleotides. Here, we focus on the detection of mutations and epigenetic markers using such devices. Based on quantum mechanical simulations within the density functional theory approach coupled with the non-equilibrium Green's function scheme, we provide deeper insight into the inherent differences in detecting modified nucleotides. Our results strongly underline the influence of the type of functionalization molecule of the nanogap, as well its conformational details within the nanogap, on the sensing efficiency of the device. The electronic features for the mutations and epigenetic markers are compared to those for the respective canonical nucleotides that are detected by different devices. The calculations directly correlate the structural and electronic properties of the different nucleotides with the electronic transmission across the diamondoid-based device. The latter was found to be controlled by the functionalizing molecule and its binding to the nucleotides. We report on the direct connection of these characteristics to the sensitivity of the diamondoid-functionalized nanogaps, which could eventually be embedded in a nanopore device, and discuss the implications for DNA sensing.

Place, publisher, year, edition, pages
2017. Vol. 7, no 68, p. 43064-43072
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-335533DOI: 10.1039/c7ra06889aISI: 000409548200047OAI: oai:DiVA.org:uu-335533DiVA, id: diva2:1163735
Funder
Swedish Research CouncilCarl Tryggers foundation Available from: 2017-12-07 Created: 2017-12-07 Last updated: 2017-12-07Bibliographically approved

Open Access in DiVA

fulltext(1384 kB)8 downloads
File information
File name FULLTEXT01.pdfFile size 1384 kBChecksum SHA-512
baf7dad50d01d2a8857bde32d7043b62a9a2c7f576da1702d8c88b0f56be3260d73e3cb17d3f4c05b6996db3839b0c4c553e82b2b70b16112de0b1b59979e00b
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Amorim, Rodrigo G.Scheicher, Ralph H.
By organisation
Materials Theory
In the same journal
RSC Advances
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 8 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 160 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf