Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
IDAC-Dose 2.1, an internal dosimetry program for diagnostic nuclear medicine based on the ICRP adult reference voxel phantoms
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
2017 (English)In: EJNMMI Research, ISSN 2191-219X, E-ISSN 2191-219X, Vol. 7, article id 88Article in journal (Refereed) Published
Abstract [en]

Background: To date, the estimated radiation-absorbed dose to organs and tissues in patients undergoing diagnostic examinations in nuclear medicine is derived via calculations based on models of the human body and the biokinetic behaviour of the radiopharmaceutical. An internal dosimetry computer program, IDAC-Dose2.1, was developed based on the International Commission on Radiological Protection (ICRP)-specific absorbed fractions and computational framework of internal dose assessment given for reference adults in ICRP Publication 133. The program uses the radionuclide decay database of ICRP Publication 107 and considers 83 different source regions irradiating 47 target tissues, defining the effective dose as presented in ICRP Publications 60 and 103. The computer program was validated against another ICRP dosimetry program, Dose and Risk Calculation (DCAL), that employs the same computational framework in evaluation of occupational and environmental intakes of radionuclides. IDAC-Dose2.1 has a sub-module for absorbed dose calculations in spherical structures of different volumes and composition; this sub-module is intended for absorbed dose estimates in radiopharmaceutical therapy. For nine specific alpha emitters, the absorbed dose contribution from their decay products is also included in the committed absorbed dose calculations. Results: The absorbed doses and effective dose of I-131-iodide determined by IDAC-Dose2.1 were validated against the dosimetry program DCAL, showing identical results. IDAC-Dose2.1 was used to calculate absorbed doses for intravenously administered F-18-FDG and orally administered Tc-99m-pertechnetate and I-131-iodide, three frequently used radiopharmaceuticals. Using the tissue weighting factors from ICRP Publication 103, the effective dose per administered activity was estimated to be 0.016 mSv/MBq for F-18-FDG, 0.014 mSv/MBq for Tc-99m-pertechnetate, and 16 mSv/MBq for I-131-iodide. Conclusions: The internal dosimetry program IDAC-Dose2.1 was developed and applied to three radiopharmaceuticals for validation against DCAL and to generate improved absorbed dose estimations for diagnostic nuclear medicine using specific absorbed fraction values of the ICRP computational voxel phantoms. The sub-module for absorbed dose calculations in spherical structures 1 mm to 9 cm in diameter and different tissue composition was included to broaden the clinical usefulness of the program. The IDAC-Dose2.1 program is free software for research and available for download at http://www.idac-dose.org.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2017. Vol. 7, article id 88
Keyword [en]
Internal dosimetry, ICRP, IDAC, DCAL, Effective dose, Radiopharmaceuticals, Diagnostic nuclear dicine
National Category
Radiology, Nuclear Medicine and Medical Imaging Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:umu:diva-141966DOI: 10.1186/s13550-017-0339-3ISI: 000414462200001PubMedID: 29098485OAI: oai:DiVA.org:umu-141966DiVA, id: diva2:1163273
Available from: 2017-12-06 Created: 2017-12-06 Last updated: 2018-01-13Bibliographically approved

Open Access in DiVA

fulltext(2684 kB)38 downloads
File information
File name FULLTEXT01.pdfFile size 2684 kBChecksum SHA-512
b2087d9e2be5c9c602d062dd602e8a4b036af490b33cb21da316811b5193000a15a0aedee58067c12ab8bd0aeb3795cd0ea619d8703ed14a91db086ab5270625
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Andersson, MartinJohansson, Lennart
By organisation
Radiation Physics
In the same journal
EJNMMI Research
Radiology, Nuclear Medicine and Medical ImagingOccupational Health and Environmental Health

Search outside of DiVA

GoogleGoogle Scholar
Total: 38 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 65 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf