Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sensitization profiles to peanut allergens across the United States
Lab Corp Amer, 1447 York Court Rd, Burlington, NC 27216 USA..
Phadia US Inc, Thermo Fisher Sci, Portage, MI USA..
Thermo Fisher Sci, Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research. Thermo Fisher Sci, Uppsala, Sweden.
Show others and affiliations
2017 (English)In: Annals of Allergy, Asthma & Immunology, ISSN 1081-1206, E-ISSN 1534-4436, Vol. 119, no 3, p. 262-266Article in journal (Refereed) Published
Abstract [en]

Background: Measurement of IgE antibody to peanut components can aid in the prediction of allergic responses the food.

Objective: To investigate the association between patient demographics (age, location) and allergic sensitization to peanut components across the United States.

Methods: Serum samples from 12,155 individuals with peanut extract specific IgE levels of 0.35 kUA/L or higher were analyzed for IgE antibodies to Ara h 1, 2, 3, 8, and 9 by ImmunoCAP.

Results: Among this population of peanut sensitized individuals, 79.1% of children (<3 years old) were sensitized to one or more peanut storage proteins (Ara h 1, 2, and/or 3), in contrast to 64.2% of adolescents (12-15 years old) and 22.1% of adults (>20 years old). Although sensitization was more prevalent to Ara h 2 than to the other storage proteins, a sizable fraction of patients were sensitized to Ara h 1 and/or 3 but not to Ara h 2 (eg, 13% of children <3 years old). Moreover, 9.6% of children, 10.2% of adolescents, and 10.5% of adults were sensitized to Ara h 9, whereas 2.4% of children, 49.4% of adolescents, and 42.9% of adults produced IgE to Ara h 8 (pathogenesis-related protein 10). Sensitization to Ara h 8 alone was markedly higher in the Northeastern United States relative to other regions of the country.

Conclusion: We conclude that sensitization to individual peanut components is highly dependent on age and geographic location. Given that a severe allergic reaction to peanut is unlikely in individuals with isolated sensitization to Ara h 8, a sizable fraction of patients, in particular adolescents and adults, may be at lower risk than anticipated based only on demonstration of sensitization to whole peanut extract.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2017. Vol. 119, no 3, p. 262-266
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-335410DOI: 10.1016/j.anai.2017.06.021ISI: 000410691200014PubMedID: 28890021OAI: oai:DiVA.org:uu-335410DiVA, id: diva2:1163124
Available from: 2017-12-06 Created: 2017-12-06 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

fulltext(510 kB)7 downloads
File information
File name FULLTEXT01.pdfFile size 510 kBChecksum SHA-512
ba072b9525a8c1e950a8fb95c0fe40e18a8e84c1cf96fa8605b1456b0a0348514621fbe1953f2225bb24efc805acb57cd841b236012ffa0b2c6843536fa8c4c6
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Borres, Magnus P
By organisation
Paediatric Inflammation Research
In the same journal
Annals of Allergy, Asthma & Immunology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 7 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 23 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf