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Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.ORCID iD: 0000-0002-2979-679X
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.ORCID iD: 0000-0003-1258-8297
2017 (English)In: Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, E-ISSN 1432-0843, Vol. 80, no 2, p. 343-353Article in journal (Refereed) Published
Abstract [en]

Purpose To investigate whether a more frequent monitoring of the absolute neutrophil counts (ANC) during myelo-suppressive chemotherapy, together with model-based predictions, can improve therapy management, compared to the limited clinical monitoring typically applied today. Methods Daily ANC in chemotherapy-treated cancer patients were simulated from a previously published population model describing docetaxel-induced myelosuppression. The simulated values were used to generate predictions of the individual ANC time-courses, given the myelosuppression model. The accuracy of the predicted ANC was evaluated under a range of conditions with reduced amount of ANC measurements. Results The predictions were most accurate when more data were available for generating the predictions and when making short forecasts. The inaccuracy of ANC predictions was highest around nadir, although a high sensitivity (>= 90%) was demonstrated to forecast Grade 4 neutropenia before it occurred. The time for a patient to recover to baseline could be well forecasted 6 days (+/- 1 day) before the typical value occurred on day 17. Conclusions Daily monitoring of the ANC, together with model-based predictions, could improve anticancer drug treatment by identifying patients at risk for severe neutropenia and predicting when the next cycle could be initiated.

Place, publisher, year, edition, pages
2017. Vol. 80, no 2, p. 343-353
Keywords [en]
Self-monitoring of ANC, Model-based predictions, Chemotherapy-induced myelosuppression, Docetaxel
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-333512DOI: 10.1007/s00280-017-3366-xISI: 000406638200012OAI: oai:DiVA.org:uu-333512DiVA, id: diva2:1162971
Funder
Swedish Cancer SocietyAvailable from: 2017-12-05 Created: 2017-12-05 Last updated: 2018-01-13Bibliographically approved

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Netterberg, IdaNielsen, Elisabet I.Friberg, Lena EKarlsson, Mats O.
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