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Relationships between serum-induced AhR bioactivity or mitochondrial inhibition and circulating polychlorinated biphenyls (PCBs)
Kyung Hee Univ, Dept Physiol, Coll Med, Seoul 02447, South Korea..
Kyung Hee Univ, Dept Physiol, Coll Med, Seoul 02447, South Korea..
Eulji Univ, Dept Internal Med, Coll Med, Seoul 01830, South Korea..
Orebro Univ, Sch Sci & Technol, MTM Res Ctr, SE-70182 Orebro, Sweden..
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2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 9383Article in journal (Refereed) Published
Abstract [en]

Metabolic syndrome and mitochondrial dysfunction have been linked to elevated serum levels of persistent organic pollutants (POPs). However, it is not clear which specific POPs contribute to aryl hydrocarbon receptor (AhR)-dependent bioactivity or inhibit mitochondrial function in human subjects. Here, we measured the cumulative bioactivity of AhR ligand mixture (AhR bioactivity) and the effects on mitochondrial function (ATP concentration) in recombinant Hepa1c1c7 cells incubated with raw serum samples obtained from 911 elderly subjects in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. Plasma concentrations of 30 POPs and plastic chemicals have previously been determined in the same PIVUS subjects. Linear regression analysis demonstrated that total toxic equivalence (TEQ) values and polychlorinated biphenyls (PCBs) were significantly correlated with AhR bioactivity (positively) and ATP concentration (negatively). Serum AhR bioactivities were positively associated with some PCBs, regardless of their dioxin-like properties, but only dioxin-like PCBs stimulated AhR bioactivity. By contrast, PCBs mediated a reduction in ATP content independently of their dioxin-like properties. This study suggests that AhR bioactivity and ATP concentrations in serum-treated cells may be valuable surrogate biomarkers of POP exposure and could be useful for the estimation of the effects of POPs on human health.

Place, publisher, year, edition, pages
Nature Publishing Group, 2017. Vol. 7, article id 9383
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Pharmacology and Toxicology
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URN: urn:nbn:se:uu:diva-335235DOI: 10.1038/s41598-017-09774-1ISI: 000408441600107PubMedID: 28839207OAI: oai:DiVA.org:uu-335235DiVA, id: diva2:1162780
Available from: 2017-12-05 Created: 2017-12-05 Last updated: 2018-01-13Bibliographically approved

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