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Long working hours as a risk factor for atrial fibrillation: a multi-cohort study
UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.;Univ Helsinki, Fac Med, Clinicum, Tukholmankatu 8 B, FIN-00290 Helsinki, Finland.;Finnish Inst Occupat Hlth, Topeliuksenkatu 41 B, Helsinki 00250, Finland..
Univ Helsinki, Fac Med, Clinicum, Tukholmankatu 8 B, FIN-00290 Helsinki, Finland..
UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland..
Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, 677 Huntington Ave,Kresge Bldg,7th Floor, Boston, MA 02115 USA..
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2017 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 38, no 34, p. 2621-2628Article in journal (Refereed) Published
Abstract [en]

Aims: Studies suggest that people who work long hours are at increased risk of stroke, but the association of long working hours with atrial fibrillation, the most common cardiac arrhythmia and a risk factor for stroke, is unknown. We examined the risk of atrial fibrillation in individuals working long hours (>= 55 per week) and those working standard 35-40 h/week.

Methods and results: In this prospective multi-cohort study from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium, the study population was 85 494 working men and women (mean age 43.4 years) with no recorded atrial fibrillation. Working hours were assessed at study baseline (1991-2004). Mean follow-up for incident atrial fibrillation was 10 years and cases were defined using data on electrocardiograms, hospital records, drug reimbursement registers, and death certificates. We identified 1061 new cases of atrial fibrillation (10-year cumulative incidence 12.4 per 1000). After adjustment for age, sex and socioeconomic status, individuals working long hours had a 1.4-fold increased risk of atrial fibrillation compared with those working standard hours (hazard ratio = 1.42, 95% CI= 1.13-1.80, P= 0.003). There was no significant heterogeneity between the cohort-specific effect estimates (I-2= 0%, P = 0.66) and the finding remained after excluding participants with coronary heart disease or stroke at baseline or during the follow-up (N= 2006, hazard ratio= 1.36, 95% CI= 1.05-1.76, P = 0.0180). Adjustment for potential confounding factors, such as obesity, risky alcohol use and high blood pressure, had little impact on this association.

Conclusion: Individuals who worked long hours were more likely to develop atrial fibrillation than those working standard hours.

Place, publisher, year, edition, pages
2017. Vol. 38, no 34, p. 2621-2628
Keywords [en]
Atrial fibrillation, Life stress, Risk factors, Cohort study
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-335207DOI: 10.1093/eurheartj/ehx324ISI: 000409542800012PubMedID: 28911189OAI: oai:DiVA.org:uu-335207DiVA, id: diva2:1162445
Available from: 2017-12-04 Created: 2017-12-04 Last updated: 2017-12-04Bibliographically approved

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Publisher's full textPubMedhttps://academic.oup.com/eurheartj/article/38/34/2621/3958185

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