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The effect of albumin and fibrinogen on the corrosion and metal release from a biomedical CoCrMo alloy
KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering. KTH.
2017 (English)Independent thesis Advanced level (degree of Master (Two Years)), 80 credits / 120 HE creditsStudent thesis
Abstract [en]

Corrosion and metal release mechanisms of CoCrMo alloys are at human biological conditions not fully understood. The main objective of this master thesis was to investigate whether the Vroman effect influences the extent of metal release from CoCrMo alloy in mixed protein solutions. The project focuses on the corrosion properties and release of cobalt (Co), chromium (Cr) and molybdenum (Mo) from a CoCrMo alloy into simulated physiological solutions of pH 7.2-7.4 in the presence of proteins.

The metal release study was performed in phosphate buffered saline (PBS) for 4 and 24 h at 37 °C with and without different concentration of proteins (bovine serum albumin-BSA and fibrinogen-Fbn from bovine plasma). In order to investigate whether any Vroman effect could affect the extent of released metals in solutions, sequential tests were performed by sampling after 1, 4, 6 and 24 h in solutions that were partially replenished after 5 h. Significant metal-induced protein aggregation and precipitation were observed in solutions of physiologically-relevant protein concentrations (40 g/L BSA and 2.67 g/L Fbn). Cr was strongly enriched in the surface oxide of CoCrMo after exposure in all solutions. This was for all solutions accompanied by metal release processes dominated by Co. Based on electrochemical investigations, the electrochemical activity did not increase, but rather decreased, in protein-containing solutions as compared to PBS alone. This could possibly be explained by blocking of cathodic areas as a result of protein adsorption. 

Place, publisher, year, edition, pages
2017. , p. 35
Keyword [en]
CoCrMo alloy, metal release, corrosion resistance, albumin, fibrinogen
National Category
Materials Engineering Corrosion Engineering
Identifiers
URN: urn:nbn:se:kth:diva-219010OAI: oai:DiVA.org:kth-219010DiVA, id: diva2:1161804
Subject / course
Materials Science and Engineering
Educational program
Master of Science - Materials Science and Engineering
Presentation
2017-10-17, DROTTNING KRISTINAS VÄG 51, Stockholm, 10:35 (English)
Supervisors
Examiners
Available from: 2017-12-01 Created: 2017-12-01 Last updated: 2017-12-01Bibliographically approved

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CiteExportLink to record
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