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Quantifying the Transition from Active Surveillance to Watchful Waiting Among Men with Very Low-risk Prostate Cancer
Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.;Akad Sjukhuset, Reg Canc Ctr Uppsala, Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Lund Univ, Div Urol Canc, Dept Translat Med Urol, Lund, Sweden.;Cambridge Univ Hosp, Dept Urol, CamPARI Clin, Cambridge, England..
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2017 (English)In: European Urology, ISSN 0302-2838, E-ISSN 1873-7560, Vol. 72, no 4, p. 534-541Article in journal (Refereed) Published
Abstract [en]

Background: Active surveillance (AS) is commonly used for men with low-risk prostate cancer (PCa). When life expectancy becomes too short for curative treatment to be beneficial, a change from AS to watchful waiting (WW) follows. Little is known about this change since it is rarely documented in medical records.

Objective: To model transition from AS to WW and how this is affected by age and comorbidity among men with very low-risk PCa.

Design, setting, and participants: National population-based healthcare registers were used for analysis.

Outcome measurements and statistical analysis: Using data on PCa characteristics, age, and comorbidity, a state transition model was created to estimate the probability of changes between predefined treatments to estimate transition from AS to WW.

Results and limitations: Our estimates indicate that 48% of men with very low-risk PCa starting AS eventually changed to WW over a life course. This proportion increased with age at time of AS initiation. Within 10 yr from start of AS, 10% of men aged 55 yr and 50% of men aged 70 yr with no comorbidity at initiation changed to WW. Our prevalence simulation suggests that the number of men on WW who were previously on AS will eventually stabilise after 30 yr. A limitation is the limited information from clinical follow-up visits (eg, repeat biopsies).

Conclusions: We estimated that changes from AS to WW become common among men with very low-risk PCa who are elderly. This potential change to WW should be discussed with men starting on AS. Moreover, our estimates may help in planning health care resources allocated to men on AS, as the transition to WW is associated with lower demands on outpatient resources.

Patient summary: Changes from active surveillance to watchful waiting will become more common among men with very low-risk prostate cancer. These observations suggest that patients need to be informed about this potential change before they start on active surveillance.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2017. Vol. 72, no 4, p. 534-541
Keywords [en]
Active surveillance, Prostate cancer, Watchful waiting, Comorbidity
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-334734DOI: 10.1016/j.eururo.2016.10.031ISI: 000410389900022PubMedID: 27816297OAI: oai:DiVA.org:uu-334734DiVA, id: diva2:1161036
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 825-2012-5047Swedish Cancer Society, 14-0570Available from: 2017-11-29 Created: 2017-11-29 Last updated: 2017-11-29Bibliographically approved

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