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Drosophila muscles regulate the immune response against wasp infection via carbohydrate metabolism
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Hultmark)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Institute of Biomedical Technology, University of Tampere, Tampere, Finland. (Hultmark)ORCID iD: 0000-0002-6506-5855
2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 15713Article in journal (Refereed) Published
Abstract [en]

We recently found that JAK/STAT signaling in skeletal muscles is important for the immune response of Drosophila larvae against wasp infection, but it was not clear how muscles could affect the immune response. Here we show that insulin signaling is required in muscles, but not in fat body or hemocytes, during larval development for an efficient encapsulation response and for the formation of lamellocytes. This effect requires TOR signaling. We show that muscle tissue affects the immune response by acting as a master regulator of carbohydrate metabolism in the infected animal, via JAK/STAT and insulin signaling in the muscles, and that there is indirect positive feedback between JAK/STAT and insulin signaling in the muscles. Specifically, stimulation of JAK/STAT signaling in the muscles can rescue the deficient immune response when insulin signaling is suppressed. Our results shed new light on the interaction between metabolism, immunity, and tissue communication.

Place, publisher, year, edition, pages
Nature Publishing Group, 2017. Vol. 7, article id 15713
Keywords [en]
Drosophila, innate immunity, hemocytes, parasitoid wasps, Jak/Stat signaling, insulin, glycogen
National Category
Immunology Cell and Molecular Biology
Research subject
Molecular Immunology
Identifiers
URN: urn:nbn:se:umu:diva-142164DOI: 10.1038/s41598-017-15940-2ISI: 000415282900028PubMedID: 29146985OAI: oai:DiVA.org:umu-142164DiVA, id: diva2:1159934
Funder
Swedish Research CouncilSwedish Cancer SocietyThe Kempe FoundationsAcademy of FinlandAvailable from: 2017-11-24 Created: 2017-11-24 Last updated: 2018-06-09Bibliographically approved

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