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High RBM3 expression is associated with an improved survival and oxaliplatin response in patients with metastatic colorectal cancer
Lund Univ, Skane Univ Hosp, Div Oncol & Pathol, Dept Clin Sci, Lund, Sweden..
Univ Bergen, Haukeland Univ Hosp, Dept Oncol, Bergen, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Uppsala Univ, Uppsala Univ Hosp, Sect Pathol, Uppsala, Sweden.ORCID iD: 0000-0003-2777-8114
Odense Univ Hosp, Dept Oncol, Odense, Denmark..
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2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 8, article id e0182512Article in journal (Refereed) Published
Abstract [en]

Background: High expression of the RNA-binding motif protein 3 (RBM3) has been shown to correlate, with prolonged survival in several malignant diseases and with the benefit of platinumbased chemotherapy in ovarian cancer. The aim of this study was to evaluate RBM3 in metastatic colorectal cancer (mCRC) as a prognostic factor for overall survival and in relation to benefit of first-line chemotherapy.

Methods: Immunohistochemical staining was conducted and evaluated in tumours from 455 mCRC patients. Kaplan- Meier analysis and Cox regression proportional hazards models were used to access the impact of RBM3 expression on overall survival (OS) and progressionfree survival (PFS).

Results: High RBM3 expression, both nuclear and cytoplasmic, was an independent prognostic factor for prolonged OS (hazard ratio [HR] 0.67, 95% confidence interval [CI] 0.50-0.90 and HR 0.66, 95% CI 0.48-0.91, respectively). PFS was significantly longer in patients with high RBM3 expression who had received first-line oxaliplatin based treatment, compared to those who had received irinotecan based treatment, both regarding nuclear and cytoplasmic expression (p-value 0.020 and 0.022 respectively).

Conclusion: High RBM3 expression is an independent predictor of prolonged survival in mCRC patients, in particular in patients treated with first-line oxaliplatin based chemotherapy.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE , 2017. Vol. 12, no 8, article id e0182512
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-334311DOI: 10.1371/journal.pone.0182512ISI: 000407431800019PubMedID: 28800641OAI: oai:DiVA.org:uu-334311DiVA, id: diva2:1159798
Funder
Swedish Research CouncilSwedish Cancer SocietyThe Kamprad Family FoundationKnut and Alice Wallenberg FoundationGunnar Nilsson Cancer Foundation
Available from: 2017-11-23 Created: 2017-11-23 Last updated: 2017-11-29Bibliographically approved

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