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Induction of labor versus expectant management of large-for-gestational-age infants in nulliparous women
Karolinska Univ Hosp & Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden.;Visby Hosp, Dept Obstet & Gynecol, Visby, Sweden..
Univ Calif Davis, Dept Surg, Davis, CA 95616 USA.;Calif Pacific Med Ctr, Dept Obstet & Gynecol, San Francisco, CA USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetric research. Karolinska Univ Hosp & Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden.
Karolinska Univ Hosp & Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden.;Karolinska Inst, Div Obstet & Gynecol, Dept Womens & Childrens Hlth, Stockholm, Sweden..
2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 7, article id e0180748Article in journal (Refereed) Published
Abstract [en]

Background There is no apparent consensus on obstetric management, i.e., induction of labor or expectant management of women with suspected large-for-gestational-age (LGA)-fetuses. Methods and findings To further examine the subject, a nationwide population-based cohort study from the Swedish Medical Birth Register in nulliparous non-diabetic women with singleton, vertex LGA (> 90 th centile) births, 1992-2013, was performed. Delivery of a live-born LGA infant induced at 38 completed weeks of gestation in non-preeclamptic pregnancies, was compared to those of expectant management, with delivery at 39, 40, 41, or 42 completed weeks of gestation and beyond, either by labor induction or via spontaneous labor. Primary outcome was mode of delivery. Secondary outcomes included obstetric anal sphincter injury, 5-minute Apgar< 7 and birth injury. Multivariable logistic regression analysis was performed to control for potential confounding. We found that among the 722 women induced at week 38, there was a significantly increased risk of cesarean delivery (aOR = 1.44 95% CI: 1.20-1.72), compared to those with expectant management (n = 44 081). There was no significant difference between the groups in regards to risk of instrumental vaginal delivery (aOR = 1.05, 95% CI: 0.85-1.30), obstetric anal sphincter injury (aOR = 0.81, 95% CI: 0.55-1.19), nor 5minute Apgar<7 (aOR = 1.06, 95% CI: 0.58-1.94) or birth injury (aOR = 0.82, 95% CI: 0.49- 1.38). Similar comparisons for induction of labor at 39, 40 or 41 weeks compared to expectant management with delivery at a later gestational age, showed increased rates of cesarean delivery for induced women. Conclusions In women with LGA infants, induction of labor at 38 weeks gestation is associated with increased risk of cesarean delivery compared to expectant management, with no difference in neonatal morbidity.

Place, publisher, year, edition, pages
2017. Vol. 12, no 7, article id e0180748
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-333609DOI: 10.1371/journal.pone.0180748ISI: 000406634500028PubMedID: 28727729OAI: oai:DiVA.org:uu-333609DiVA, id: diva2:1157998
Funder
Swedish Research Council, 2013-2429, 2014-3561Stockholm County Council, 20130156
Available from: 2017-11-17 Created: 2017-11-17 Last updated: 2017-11-29Bibliographically approved

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