Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England.;Univ Hertfordshire, Sch Life & Med Sci, Coll Lane, Hatfield AL10 9AB, Herts, England..
Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England..
Univ Coll Dublin, Conway Inst, Nutrigen Res Grp, Dublin, Ireland..
Univ Cordoba, IMIBIC, Reina Sofia Univ Hosp, Lipids & Atherosclerosis Unit, Cordoba, Spain..
Show others and affiliations
2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 6274Article in journal (Refereed) Published
Abstract [en]

Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.

Place, publisher, year, edition, pages
2017. Vol. 7, article id 6274
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:uu:diva-333525DOI: 10.1038/s41598-017-05802-2ISI: 000406260100078PubMedID: 28740125OAI: oai:DiVA.org:uu-333525DiVA, id: diva2:1157295
Funder
EU, European Research Council, FOOD-CT-2003-505944Available from: 2017-11-15 Created: 2017-11-15 Last updated: 2017-11-15Bibliographically approved

Open Access in DiVA

fulltext(1334 kB)9 downloads
File information
File name FULLTEXT01.pdfFile size 1334 kBChecksum SHA-512
d8f1c5d51d49a45b5267df4d808965e46f2651f18a1c4786f3dbe82d2a79786b54e60ade7a91705c09c8049b348c09dd3ed664c920d6380b1fda41ccfd5de0ae
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Risérus, Ulf
By organisation
Clinical Nutrition and Metabolism
In the same journal
Scientific Reports
Nutrition and Dietetics

Search outside of DiVA

GoogleGoogle Scholar
Total: 9 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 183 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf