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Cytotoxic Effects of Sarcophyton sp Soft Corals-Is There a Correlation to Their NMR Fingerprints?
Cairo Univ, Coll Pharm, Pharmacognosy Dept, Kasr El Aini St,PB 11562, Cairo, Egypt..
Cairo Univ, Coll Pharm, Pharmacognosy Dept, Kasr El Aini St,PB 11562, Cairo, Egypt..
Natl Inst Oceanog & Fisheries, Red Sea Branch, Hurghada 84511, Egypt..
Cairo Univ, Coll Pharm, Pharmacognosy Dept, Kasr El Aini St,PB 11562, Cairo, Egypt..
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2017 (English)In: Marine Drugs, ISSN 1660-3397, E-ISSN 1660-3397, Vol. 15, no 7, article id 211Article in journal (Refereed) Published
Abstract [en]

Sarcophyton sp. soft corals are rich in cembranoid diterpenes, which represent the main chemical defense of corals against their natural predators in addition to their myriad biological effects in humans. Quantitative NMR (qNMR) was applied for assessing the diterpene variation in 16 soft coral specimens in the context of their genotype, origin, and growing habitat. qNMR revealed high diterpene levels in Sarcophyton sp. compared to Sinularia and Lobophyton, with (ent)sarcophines as major components (17-100 mu g/mg) of the coral tissues. Multivariate data analysis was employed to classify samples based on the quantified level of diterpenes, and compared to the untargeted NMR approach. Results revealed that qNMR provided a stronger classification model of Sarcophyton sp. than untargeted NMR fingerprinting. Additionally, cytotoxicity of soft coral crude extracts was assessed against androgen-dependent prostate cancer cell lines (PC3) and androgen-independent colon cancer cell lines (HT-29), with IC50 values ranging from 10-60 mu g/mL. No obvious correlation between the extracts' IC50 values and their diterpene levels was found using either Spearman or Pearson correlations. This suggests that this type of bioactivity may not be easily predicted by NMR metabolomics in soft corals, or is not strongly correlated to measured diterpene levels.

Place, publisher, year, edition, pages
2017. Vol. 15, no 7, article id 211
Keywords [en]
cembranoids, Sarcophyton, metabolomics, quantitative nuclear magnetic resonance (qNMR), terpenoids
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-333529DOI: 10.3390/md15070211ISI: 000406685900019OAI: oai:DiVA.org:uu-333529DiVA, id: diva2:1157237
Available from: 2017-11-15 Created: 2017-11-15 Last updated: 2018-01-13Bibliographically approved

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