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The house spider genome reveals an ancient whole-genome duplication during arachnid evolution
Oxford Brookes Univ, Dept Biol & Med Sci, Gipsy Lane, Oxford OX3 0BP, England.;Univ Massachusetts Lowell, Dept Biol Sci, 198 Riverside St, Lowell, MA 01854 USA..
Univ Wisconsin Madison, Dept Zool, 430 Lincoln Dr, Madison, WI 53706 USA..
Washington & Lee Univ, Dept Biol, 204 West Washington St, Lexington, VA 24450 USA.;Univ Calif Riverside, Dept Biol, Riverside, CA 92521 USA.;J Craig Venter Inst, 9714 Med Ctr Dr, Rockville, MD 20850 USA..
Oxford Brookes Univ, Dept Biol & Med Sci, Gipsy Lane, Oxford OX3 0BP, England..
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2017 (English)In: BMC Biology, ISSN 1741-7007, E-ISSN 1741-7007, Vol. 15, 62Article in journal (Refereed) Published
Abstract [en]

Background: The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum.

Results: We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication.

Conclusions: Our results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD , 2017. Vol. 15, 62
Keyword [en]
Parasteatoda tepidariorum, Genome, Centruroides sculpturatus, Gene duplication, Evolution, Hox genes
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-332833DOI: 10.1186/s12915-017-0399-xISI: 000406537400001PubMedID: 28756775OAI: oai:DiVA.org:uu-332833DiVA: diva2:1155898
Funder
Swedish Research Council, 621-2011-4703
Available from: 2017-11-09 Created: 2017-11-09 Last updated: 2017-11-09Bibliographically approved

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Janssen, Ralf

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