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Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis
Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Australia and Academic Center for Geriatric Dentistry, Karolinska Institutet, Sweden.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences. Academic Center for Geriatric Dentistry, Karolinska Institutet, Sweden.ORCID iD: 0000-0001-9309-543X
Academic Center for Geriatric Dentistry, Karolinska Institutet and Department of Dental Medicine, Karolinska Institutet, Sweden.
Aging Research Center, Department of Neurobiology, Karolinska Institutet and Stockholm University, Sweden.
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2017 (English)In: Journal of The American Geriatrics Society, ISSN 0002-8614, E-ISSN 1532-5415Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVES: To assess and quantify the risk of drug-induced dry mouth as a side effect in older people. DESIGN: Systematic review and meta analysis. SETTING: A search of the literature was undertaken using Medline, Embase, Cochrane, Web of Science, and PubMed from 1990 to 2016. PARTICIPANTS: Older people (aged ≥60) who participated in intervention or observational studies investigating drug use as an exposure and xerostomia or salivary gland hypofunction as adverse drug outcomes. MEASUREMENTS: Two pairs of authors screened titles and abstracts of studies for relevance. Two authors independently extracted data, including study characteristics, definitions of exposure and outcome, and methodological quality. For the metaanalyses, random-effects models were used for pooling the data and I2 statistics for exploring heterogeneity. RESULTS: Of 1,544 potentially relevant studies, 52 were deemed eligible for inclusion in the final review and 26 in meta analyses. The majority of studies were of moderate methodological quality. In the intervention studies, urological medications (odds ratio (OR) = 5.91, 95% confidence interval (CI) = 4.04–8.63; I2 = 62%), antidepressants (OR = 4.74, 95% CI = 2.69–8.32, I2 = 21%), and psycholeptics (OR = 2.59, 95% CI = 1.79–3.95, I2 = 0%) were significantly associated with dry mouth. In the observational studies, numbers of medications and several medication classes were significantly associated with xerostomia and salivary gland hypofunction.

Place, publisher, year, edition, pages
2017.
Keyword [en]
xerostomia; dry mouth; medication; systematic review; metaanalysis
National Category
Medical and Health Sciences Geriatrics
Research subject
Public Health Science
Identifiers
URN: urn:nbn:se:kau:diva-65019DOI: 10.1111/jgs.15151OAI: oai:DiVA.org:kau-65019DiVA: diva2:1153409
Available from: 2017-10-30 Created: 2017-10-30 Last updated: 2017-11-01

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Publisher's full texthttp://onlinelibrary.wiley.com/doi/10.1111/jgs.15151/abstract

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