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Prostate cancer detection with a tactile resonance sensor: measurement considerations and clinical setup
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).ORCID iD: 0000-0002-2440-9543
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology.
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2017 (English)In: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 17, no 11, article id 2453Article in journal (Refereed) Published
Abstract [en]

Tumors in the human prostate are usually stiffer compared to surrounding non-malignant glandular tissue, and tactile resonance sensors measuring stiffness can be used to detect prostate cancer. To explore this further, we used a tactile resonance sensor system combined with a rotatable sample holder where whole surgically removed prostates could be attached to detect tumors on, and beneath, the surface ex vivo. Model studies on tissue phantoms made of silicone and porcine tissue were performed. Finally, two resected human prostate glands were studied. Embedded stiff silicone inclusions placed 4 mm under the surface could be detected in both the silicone and biological tissue models, with a sensor indentation of 0.6 mm. Areas with different amounts of prostate cancer (PCa) could be distinguished from normal tissue (p < 0.05), when the tumor was located in the anterior part, whereas small tumors located in the dorsal aspect were undetected. The study indicates that PCa may be detected in a whole resected prostate with an uneven surface and through its capsule. This is promising for the development of a clinically useful instrument to detect prostate cancer during surgery.

Place, publisher, year, edition, pages
Switzerland: MDPI AG , 2017. Vol. 17, no 11, article id 2453
Keyword [en]
tissue stiffness, resonance sensor, tactile sensor, prostate cancer, piezoelectric sensor
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:umu:diva-141158DOI: 10.3390/s17112453ISI: 000416790500015OAI: oai:DiVA.org:umu-141158DiVA, id: diva2:1152799
Available from: 2017-10-26 Created: 2017-10-26 Last updated: 2018-01-15Bibliographically approved

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Åstrand, AndersAndersson, BrittJalkanen, VilleBörje, LjungbergAnders, BerghLindahl, Olof
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Department of Applied Physics and ElectronicsCentre for Biomedical Engineering and Physics (CMTF)Urology and AndrologyPathologyDepartment of Radiation Sciences
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