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IgE reactivity to alpha-Gal in relation to Lyme borreliosis
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Kalmar County Hospital, Sweden.
Karolinska Institute, Sweden; University Hospital, Sweden.
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
Karolinska Institute, Sweden; University Hospital, Sweden.
2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 9, article id e0185723Article in journal (Refereed) Published
Abstract [en]

Background An association between tick bites, the development of immunoglobulin E (IgE) antibodies to galactose-alpha-1, 3-galactose (alpha-Gal) and red meat allergy has recently been reported. Here we wanted to elucidate the relation between tick exposure, IgE antibodies to alpha-Gal and Lyme borreliosis (LB). Methods In the highly LB endemic area of Kalmar County, Sweden, serum samples and health inquiries from 518 blood donors were included. All sera were investigated for multiple IgG antiBorrelia antibodies using a multiplex assay (recomBead, Mikrogen). In addition, three serially collected sera over a six month period from 148 patients with clinically defined erythema migrans (EM) were included. IgE antibodies against alpha-Gal were determined using ImmunoCAP (Thermo Fisher Scientific). Results In blood donors reporting previous LB (n = 124) IgE to alpha-Gal was found in 16%, while in donors denying previous LB but with multiple anti-Borrelia antibodies (n = 94; interpreted as asymptomatic LB) 10% were IgE alpha-Gal-positive. Finally, in donors without Borrelia antibodies denying previous LB (n = 300) 14% showed IgE to alpha-Gal. No significant difference in proportions among the groups were found. In EM patients, IgE to alpha-Gal was found in 32/148 (22%) at diagnosis, 31/148 (21%) after two-three months and 23/148 (16%) after six months. A significant reduction of proportion and level of IgE to alpha-Gal was found between the second and third sample (pamp;lt; 0.01). A positive IgE anti alpha-Gal was more common among men compared with women both in blood donors and in EM patients (p amp;lt;= 0.01). Conclusions IgE to alpha-Gal reactivity was common in a tick endemic area but showed no significant relation to previous LB. IgE anti-alpha-Gal reactivity in EM patients peaked within three months of diagnosis of EM, after which it waned indicating that recent tick exposure is of importance in alpha-Gal sensitization. Furthermore, IgE anti alpha-Gal was more common in men compared with women.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE , 2017. Vol. 12, no 9, article id e0185723
National Category
Rheumatology and Autoimmunity
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URN: urn:nbn:se:liu:diva-142177DOI: 10.1371/journal.pone.0185723ISI: 000411980300080PubMedID: 28953957OAI: oai:DiVA.org:liu-142177DiVA, id: diva2:1151554
Note

Funding Agencies|Thermo Fisher Scientific, Uppsala, Sweden; Swedish Asthma and Allergy Foundation; Stockholm County Council (ALF Medicin); Swedish Research Council; Swedish Heart-Lung Foundation; Swedish Cancer and Allergy Foundation; King Gustaf V 80th Birthday Foundation; Hesselman Foundation; Konsul Th C Bergh Foundation; Magnus Bergvall Foundation; Medical Research Council in the South-east of Sweden

Available from: 2017-10-23 Created: 2017-10-23 Last updated: 2017-11-29

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