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Polymorphism of the human complement component C3- genetic and immunological aspects
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology. Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
1973 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Genetic polymorphism is by definition the occurrence in the same population of two or more alleles at one locus,each with a frequency high enough not to be maintained by recurrent mutation only (1). Among the human plasmaproteins two major categories of polymorphism have been described, allotypic and electrophoretic heterogeneity. Allotypy is defined by Oudin as individual antigenic differences among proteins within a species (2). The first discovered polymorphism of this category was the Gm system of immunoglobulin G by Grubb (3). The first described electrophoretic heterogeneity in plasma proteins was theHp (haptoglobin) system discovered by Smithies (4). Sincethen genetic variants of several other human plasma proteins have been found. This dissertation is concerned with thegenetic and immunological aspects of the polymorphism of the third component of human complement, C3.

Place, publisher, year, edition, pages
Umeå: Umeå universitet , 1973. , p. 22
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 4
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:umu:diva-141045OAI: oai:DiVA.org:umu-141045DiVA, id: diva2:1151352
Projects
digitalisering@umu.se
Available from: 2017-10-23 Created: 2017-10-23 Last updated: 2017-11-07Bibliographically approved

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CiteExportLink to record
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