Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer
Division of Medical Diagnostics, Department of Laboratory Medicine, Region Jönköping County, Jönköping, Sweden.
Division of Medical Diagnostics, Department of Clinical Physiology, Region Jönköping County, Jönköping, Sweden.
Department of Surgery, Region Jönköping County, Jönköping, Sweden.
Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
Show others and affiliations
2017 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 23, no 34, p. 6212-6219Article in journal (Refereed) Published
Abstract [en]

AIM: To investigate association of circulating inflammatory factors at the time of colorectal cancer (CRC) surgery with survival.

METHODS: Plasma levels from 174 CRC patients (69 females and 105 men), with median age 70 years (range 29-90), localized in the colon (n = 105) or rectum (n = 69), with stage I (n = 24), stage II (n = 54), stage III (n = 67) and stage IV (n = 29) were measured using commercially available Bio-Plex Pro™ Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.

RESULTS: Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.

CONCLUSION: High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis.

Place, publisher, year, edition, pages
Baishideng Publishing Group , 2017. Vol. 23, no 34, p. 6212-6219
Keywords [en]
Colorectal cancer, Cytokines, Inflammation, Mortality, Plasma, Prognosis
National Category
Gastroenterology and Hepatology Cancer and Oncology
Identifiers
URN: urn:nbn:se:hj:diva-37678DOI: 10.3748/wjg.v23.i34.6212ISI: 000410751600003PubMedID: 28974887Scopus ID: 2-s2.0-85029580861OAI: oai:DiVA.org:hj-37678DiVA, id: diva2:1150654
Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2017-10-20Bibliographically approved

Open Access in DiVA

fulltext(1056 kB)17 downloads
File information
File name FULLTEXT01.pdfFile size 1056 kBChecksum SHA-512
3a47f497ca80c36daa96d60b05631ee74e7902116543c8b7df6a0d0a2cc3038015b9cbb754baefc5722e709857295562b489c242b579f5d6283463b1629430c0
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Dimberg, Jan
By organisation
HHJ, Dep. of Natural Science and BiomedicineHHJ. Biomedical Platform
In the same journal
World Journal of Gastroenterology
Gastroenterology and HepatologyCancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 17 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 56 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf