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Lifestyle and Risk of Screening-Detected Abdominal Aortic Aneurysm in Men
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Box 210, SE-17177 Stockholm, Sweden.;Soder Sjukhuset, Dept Surg, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Box 210, SE-17177 Stockholm, Sweden..
Orebro Univ Hosp, Dept Cardiovasc Surg, Sect Vasc Surg, Orebro, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
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2017 (English)In: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 6, no 5, article id e004725Article in journal (Refereed) Published
Abstract [en]

Background-Modifiable lifestyle-related factors associated with risk of abdominal aortic aneurysm (AAA) are rarely investigated with a prospective design. We aimed to study possible associations among such factors and comorbidities with mean abdominal aortic diameter (AAD) and with risk of AAA among men screened for the disease. Methods and Results-Self-reported lifestyle-related exposures were assessed at baseline (January 1, 1998) among 14 249 men from the population-based Cohort of Swedish Men, screened for AAA between 65 and 75 years of age (mean 13 years after baseline). Multivariable prediction of mean AAD was estimated with linear regression, and hazard ratios (HRs) of AAA (AAD >= 30 mm) with Cox proportional hazard regression. The AAA prevalence was 1.2% (n=168). Smoking, body mass index, and cardiovascular disease were associated with a larger mean AAD, whereas consumption of alcohol and diabetes mellitus were associated with a smaller mean AAD. The HR of AAA was increased among participants who were current smokers with >= 25 pack-years smoked compared with never smokers (HR 15.59, 95% CI 8.96-27.15), those with a body mass index >= 25 versus <25 ( HR 1.89, 95% CI, 1.22-2.93), and those with cardiovascular disease (HR 1.77, 95% CI, 1.13-2.77), and hypercholesterolemia (HR 1.59, 95% CI 1.08-2.34). Walking or bicycling for >40 minutes/day (versus almost never) was associated with lower AAA hazard (HR 0.59, 95% CI 0.36-0.97) compared with almost never walking or bicycling. Conclusions-This prospective study confirms that modifiable lifestyle-related factors are associated with AAD and with AAA disease.

Place, publisher, year, edition, pages
2017. Vol. 6, no 5, article id e004725
Keywords [en]
abdominal aortic aneurysm, cohort study, epidemiology, lifestyle, risk factor
National Category
Surgery
Identifiers
URN: urn:nbn:se:uu:diva-329114DOI: 10.1161/JAHA.116.004725ISI: 000404098600010OAI: oai:DiVA.org:uu-329114DiVA, id: diva2:1150467
Funder
Swedish Research Council, 2015-02302, K2013-64X-20406-07-3Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2017-12-21Bibliographically approved

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Wanhainen, AndersBjörck, Martin
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