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Advanced all-fiber optofluidic devices
KTH, School of Engineering Sciences (SCI), Applied Physics, Laser Physics.
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Significant technological advances of the last years have been possible by developments in Optofluidics, which is a field that deals with the integration of optics and microfluidics into single devices.

The work described in this thesis is based on five scientific publications related to the use of fiber optic technology to build integrated optofluidic devices. The first three publications are within the field of life-science and point towards in-vivo and point-of-care applications, whereas the last two publications cover the study and the use of plasmonic nanoparticles for electrical modulation of light.

Aiming at developing useful tools for in-vivo biological applications, the first publication consists of designing and testing a functional optical fiber for real-time monitoring and selective collection of fluorescent microparticles. This probe relies on a microstructured optical fiber with a hole along its cladding, which is used to selectively aspirate individual particles of interest once their fluorescence signal is detected. On the same line of research, the second publication contemplates the fabrication of a fiber probe that traps single microparticles and allows for remote detection of their optical properties. This probe is also based on a microstructured fiber that enables particle trapping by fluidic forces. The third publication addresses the development of an all-fiber miniaturized flow cytometer for point-of-care applications. This system can analyze, with excellent accuracy and sensitivity, up to 2500 cells per second by measuring their fluorescence and scattering signal. A novel microfluidic technique, called Elasto-inertial microfluidics, is employed for aligning the cells into a single-stream to optimize detection and throughput.

The fourth publication involves the experimental and theoretical study of the electrical-induced alignment of plasmonic gold nanorods in suspension and its applicability to control light transmission. This study is done by using an all-fiber optofluidic device, based on a liquid-core fiber, which facilitates the interaction of light, electric fields, and liquid suspensions. Results show that nanorods can be aligned in microseconds, providing a much better performance than liquid-crystal devices. Finally, the fifth publication consists of an upgrade of the previous device by integrating four electrodes in the cladding of the liquid-core fiber. This improvement enables nanosecond response time and the possibility of digitally switching nanorods between two orthogonal aligned states, overcoming the limitation of slow thermal relaxation.

The work presented here shows that optofluidics based on optical fibers is a robust and convenient platform, as well as a promising direction for the developing of novel instruments in fields such as life-science, non-linear optics, plasmonic, and sensing.

Place, publisher, year, edition, pages
KTH Royal Institute of Technology, 2017. , p. 68
Series
TRITA-FYS, ISSN 0280-316X ; 2017:65
Keywords [en]
Fiber optics, functional fiber probes, optofluidics, microfluidics, plasmonic, all-fiber technology, instrumentation for life-sciences.
National Category
Medical Engineering Physical Sciences Medical Laboratory and Measurements Technologies
Research subject
Physics
Identifiers
URN: urn:nbn:se:kth:diva-215938ISBN: 978-91-7729-572-3 (print)OAI: oai:DiVA.org:kth-215938DiVA, id: diva2:1150021
Public defence
2017-11-14, FB42, Albanova, Roslagstullsbacken 21, KTH, Stockholm, 13:00 (English)
Opponent
Supervisors
Note

QC 20171018

Available from: 2017-10-18 Created: 2017-10-17 Last updated: 2017-10-18Bibliographically approved
List of papers
1. A fiber optic system for detection and collection of micrometer-size particles
Open this publication in new window or tab >>A fiber optic system for detection and collection of micrometer-size particles
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2014 (English)In: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 22, no 18, p. 21480-21487Article in journal (Refereed) Published
Abstract [en]

An optical fiber containing longitudinal holes adjacent to the core has been used to detect and collect fluorescent particles from a solution. Excitation light was launched through the fiber and fluorescence signal was guided back to a detector system. As a proof of principle, green and red fluorescent polystyrene beads were detected and selectively collected from a water solution containing a mixture of red and green fluorescent beads.

National Category
Other Physics Topics
Identifiers
urn:nbn:se:kth:diva-145318 (URN)10.1364/OE.22.021480 (DOI)000341428000033 ()2-s2.0-84907284431 (Scopus ID)
Note

Updated from submitted to published.

QC 20141003

Available from: 2014-05-15 Created: 2014-05-15 Last updated: 2017-12-05Bibliographically approved
2. Fluidic trapping and optical detection of microparticles with a functional optical fiber
Open this publication in new window or tab >>Fluidic trapping and optical detection of microparticles with a functional optical fiber
(English)In: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087Article in journal (Other academic) Submitted
Abstract [en]

A fiber probe is presented that traps single micro-sized particles and allows detection of their optical properties. The trapping mechanism used is based on fluid suction with a micro-structured optical fiber that has five holes along its cladding. Proof-of-principle experiments with a diluted solution of fluorescently labeled particles are performed. The fiber probe presented here may find various applications in life-science and environmental monitoring.  

Place, publisher, year, edition, pages
Optical Society of America
Keywords
fiber optics, single cell analysis, in vivo applications
National Category
Biomedical Laboratory Science/Technology
Identifiers
urn:nbn:se:kth:diva-215762 (URN)10.1364/OE.25.033657 (DOI)000418893200131 ()2-s2.0-85039045635 (Scopus ID)
Note

QCR 20171018

Available from: 2017-10-15 Created: 2017-10-15 Last updated: 2018-03-14Bibliographically approved
3. High performance micro-flow cytometer based on optical fibres
Open this publication in new window or tab >>High performance micro-flow cytometer based on optical fibres
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2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 5628Article in journal (Refereed) Published
Abstract [en]

Flow cytometry is currently the gold standard for analysis of cells in the medical laboratory and biomedical research. Fuelled by the need of point-of-care diagnosis, a significant effort has been made to miniaturize and reduce cost of flow cytometers. However, despite recent advances, current microsystems remain less versatile and much slower than their large-scale counterparts. In this work, an all-silica fibre microflow cytometer is presented that measures fluorescence and scattering from particles and cells. It integrates cell transport in circular capillaries and light delivery by optical fibres. Single-stream cell focusing is performed by Elasto-inertial microfluidics to guarantee accurate and sensitive detection. The capability of this technique is extended to high flow rates (up to 800 mu l/min), enabling a throughput of 2500 particles/s. The robust, portable and low-cost system described here could be the basis for a point-of-care flow cytometer with a performance comparable to commercial systems.

Place, publisher, year, edition, pages
Nature Publishing Group, 2017
National Category
Biological Sciences
Identifiers
urn:nbn:se:kth:diva-211606 (URN)10.1038/s41598-017-05843-7 (DOI)000405677200013 ()2-s2.0-85025168074 (Scopus ID)
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceSwedish Research CouncilKnut and Alice Wallenberg FoundationSwedish Childhood Cancer Foundation
Note

QC 20170814

Available from: 2017-08-14 Created: 2017-08-14 Last updated: 2017-10-17Bibliographically approved
4. Microsecond switching of plasmonic nanorods in an all-fiber optofluidic component
Open this publication in new window or tab >>Microsecond switching of plasmonic nanorods in an all-fiber optofluidic component
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2017 (English)In: Optica, ISSN 2334-2536, Vol. 4, no 8, p. 864-870Article in journal (Refereed) Published
Abstract [en]

As information technologies move from electron-to photon-based systems, the need to rapidly modulate light is of paramount importance. Here, we study the evolution of the electric-field-induced alignment of gold nanorods suspended in organic solvents. The experiments were performed using an all-fiber optofluidic device, which enables convenient interaction of light, electric fields, and the nanorod suspension. We demonstrate microsecond nanorod switching times, three orders of magnitude faster than a traditional Freederickcz-based liquid crystal alignment mechanism. We find that the dynamics of the alignment agrees well with the Einstein-Smoluchowski relationship, allowing for the determination of the rotational diffusion coefficient and polarizability anisotropy of the nanorods as well as the effective length of the ligands capping the nanorods. The ability to dynamically control the optical properties of these plasmonic suspensions coupled with the point-to-point delivery of light from the fiber component, as demonstrated in this work, may enable novel ultrafast optical switches, filters, displays, and spatial light modulators.

Place, publisher, year, edition, pages
Optical Society of America, 2017
National Category
Physical Sciences
Identifiers
urn:nbn:se:kth:diva-214333 (URN)10.1364/OPTICA.4.000864 (DOI)000407909800005 ()2-s2.0-85028296486 (Scopus ID)
Note

QC 20170913

Available from: 2017-09-13 Created: 2017-09-13 Last updated: 2018-05-24Bibliographically approved
5. Digital switching of plasmonic nanorods with nanosecond response times
Open this publication in new window or tab >>Digital switching of plasmonic nanorods with nanosecond response times
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(English)In: Article in journal (Refereed) Submitted
Abstract [en]

We demonstrate the digital electric field induced switching of plasmonic nanorods between "1" and "0" orthogonal aligned states using an electro-optic fluid fiber component.  We show by digitally switching the nanorods, that thermal rotational diffusion of the nanorods can be circumvented, demonstrating an approach to achieve submicrosecond switching times.  We also show, from an initial unaligned state, that the nanorods can be aligned into the applied electric field direction in 110 nanoseconds. The high-speed digital switching of plasmonic nanorods integrated into an all-fiber optical component may provide novel opportunities for remote sensing and signaling applications.

Keywords
Plasmonic, all-fiber devices, electro-optics modulation
National Category
Nano Technology Physical Sciences
Identifiers
urn:nbn:se:kth:diva-215939 (URN)
Note

QCR 20171018

Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2017-10-18Bibliographically approved

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