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Transancestral mapping and genetic load in systemic lupus erythematosus
Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27101 USA..
Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27101 USA..
Kings Coll London, Guys Hosp, Div Genet & Mol Med & Immunol Infect & Inflammato, London SE1 9RT, England..
Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
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2017 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, article id 16021Article in journal (Refereed) Published
Abstract [en]

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.

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NATURE PUBLISHING GROUP , 2017. Vol. 8, article id 16021
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-331233DOI: 10.1038/ncomms16021ISI: 000405680100001PubMedID: 28714469OAI: oai:DiVA.org:uu-331233DiVA, id: diva2:1149441
Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2018-02-19Bibliographically approved

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