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Label-free detection of interleukin-6 using electrolyte gated organic field effect transistors
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering. University of Modena and Reggio Emilia, Italy.
University of Modena and Reggio Emilia, Italy; University of Ferrara, Italy.
University of Modena and Reggio Emilia, Italy.
University of Modena and Reggio Emilia, Italy.
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2017 (English)In: Biointerphases, ISSN 1934-8630, E-ISSN 1559-4106, Vol. 12, no 5, article id 05F401Article in journal (Refereed) Published
Abstract [en]

Cytokines are small proteins that play fundamental roles in inflammatory processes in the human body. In particular, interleukin (IL)-6 is a multifunctional cytokine, whose increased levels are associated with infection, cancer, and inflammation. The quantification of IL-6 is therefore of primary importance in early stages of inflammation and in chronic diseases, but standard techniques are expensive, time-consuming, and usually rely on fluorescent or radioactive labels. Organic electronic devices and, in particular, organic field-effect transistors (OFETs) have been proposed in the recent years as novel platforms for label-free protein detection, exploiting as sensing unit surface-immobilized antibodies or aptamers. Here, the authors report two electrolyte-gated OFETs biosensors for IL-6 detection, featuring monoclonal antibodies and peptide aptamers adsorbed at the gate. Both strategies yield biosensors that can work on a wide range of IL-6 concentrations and exhibit a remarkable limit of detection of 1 pM. Eventually, electrolyte gated OFETs responses have been used to extract and compare the binding thermodynamics between the sensing moiety, immobilized at the gate electrode, and IL-6. (C) 2017 American Vacuum Society.

Place, publisher, year, edition, pages
AMER INST PHYSICS , 2017. Vol. 12, no 5, article id 05F401
National Category
Analytical Chemistry
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URN: urn:nbn:se:liu:diva-141922DOI: 10.1116/1.4997760ISI: 000411870800001PubMedID: 28954519OAI: oai:DiVA.org:liu-141922DiVA, id: diva2:1149204
Note

Funding Agencies|IT MIUR Bilateral Project Italy/Sweden "Poincare"; joint INFM-CNR Project; Life Science Department; "Fondazione di Vignola"

Available from: 2017-10-13 Created: 2017-10-13 Last updated: 2017-11-13

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Diacci, ChiaraSimon, Daniel
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