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Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets
Uppsala University, Sweden.
Uppsala University, Sweden.
Uppsala University, Sweden.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-5582-140X
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2017 (English)In: Endocrine Connections, ISSN 2049-3614, E-ISSN 2049-3614, Vol. 6, no 7, p. 458-468Article in journal (Refereed) Published
Abstract [en]

Islet amyloid and beta cell death in type 2 diabetes are heterogeneous events, where some islets are affected early in the disease process, whereas others remain visibly unaffected. This study investigated the possibility that inter-islet functional and vascular differences may explain the propensity for amyloid accumulation in certain islets. Highly blood-perfused islets were identified by microspheres in human islet amyloid polypeptide expressing mice fed a high-fat diet for three or 10 months. These highly blood-perfused islets had better glucose-stimulated insulin secretion capacity than other islets and developed more amyloid deposits after 10 months of high-fat diet. Similarly, human islets with a superior release capacity formed more amyloid in high glucose culture than islets with a lower release capacity. The amyloid formation in mouse islets was associated with a higher amount of prohormone convertase 1/3 and with a decreased expression of its inhibitor proSAAS when compared to islets with less amyloid. In contrast, levels of prohormone convertase 2 and expression of its inhibitor neuroendocrine protein 7B2 were unaltered. A misbalance in prohormone convertase levels may interrupt the normal processing of islet amyloid polypeptide and induce amyloid formation. Preferential amyloid load in the most blood-perfused and functional islets may accelerate the progression of type 2 diabetes.

Place, publisher, year, edition, pages
BIOSCIENTIFICA LTD , 2017. Vol. 6, no 7, p. 458-468
Keywords [en]
islet amyloid; pancreatic islets; heterogeneity; blood flow
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-141925DOI: 10.1530/EC-17-0148ISI: 000411647000007PubMedID: 28790139OAI: oai:DiVA.org:liu-141925DiVA, id: diva2:1149199
Note

Funding Agencies|Swedish Research Council [55X-15043]; Swedish Child Diabetes Foundation; Swedish Diabetes Foundation; Diabetes Wellness Sweden; Novo Nordisk Foundation; strategic grant Excellence of Diabetes Research in Sweden (EXODIAB)

Available from: 2017-10-13 Created: 2017-10-13 Last updated: 2017-11-29

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