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Effektivisering av orena lösningsmedelsströmmar på AstraZeneca
KTH, School of Chemical Science and Engineering (CHE).
KTH, School of Chemical Science and Engineering (CHE).
2017 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesisAlternative title
Optimization of polluted solvent streams at AstraZeneca (English)
Abstract [en]

This project was undertaken at one of AstraZeneca's substance factories in Södertälje, Ersättningsfabriken, EFA. The project aimed to facilitate discharge of different solvent streams from the factory.

The manufacture of drugs necessitates the use of large quantities of solvent. This creates  a  huge volume of waste to be disposed of. As waste streams leave one of the units in the factory, they are categorized based on their contents and provided with different article numbers. After  the  waste streams leave the units they are sorted and later destroyed according to their article number.

The aim of this project was to map out all those waste streams from EFA that travel via the tank cellar to the storage unit, before destruction/purification. Factors such as amount, time of depletion and the way the waste streams travel to AstraZeneca central unit for waste disposal, were evaluated. At the central unit for waste disposal the solvents are stored in destruction tanks before external or internal destruction/purification. The goal of the project was further to develop a plan to reduce the number of bottlenecks that occur whilst emptying units during production and to increase the efficiency of the emptying process.

A number of different methods were employed in order to achieve the project's goals. Practical work and a one week internship in production were combined with interviews,  data  collection  from archives, documents  and the use of different programs.

A survey of all the waste streams leaving units in the factory was produced. Furthermore, statistics regarding the load in the tanks in the tank cellar and usage of different articles were compiled. A comparison of the methods of sorting waste and the articles was made between AstraZeneca and the external company that collects the  waste. This comparison  led to a recommendation to eliminate one of the articles, as eliminationwould  enable more efficient  usage of  the tank cellar.

 

 

Abstract [sv]

Projektet genomfördes på en av AstraZenecas substansfabriker i Södertälje som heter Ersättningsfabriken, EFA, med syftet att underlätta hanteringen av avfallsströmmar från fabriken.

Vid läkemedelstillverkning används stora mängder lösningsmedel vilket leder till att stora mängder avfallsströmmar som måste tas om hand. De olika avfallsströmmarna erhåller ett artikelnummer baserat på dess innehåll då de lämnar en enhet i fabriken och sorteras samt destrueras beroende på detta artikelnummer.

Projektets inledande mål var att kartlägga alla avfallsströmmar i fabriken som leds via tankkällaren till lagring innan destruktion/rening. Faktorer som undersöktes var mängd, tömningstid och tömningsväg till AstraZenecas centrala enhet för avfallshantering. Vid den centrala enheten lagras lösningsmedlen i destruktionstankar innan extern eller intern destruktion/rening. Målet med projektet var även att reducera antalet krockar som uppstår vid tömning i produktionen då flera enheter önskar tömmas samtidigt samt att utforma en plan för att effektivisera tömningama för smidigare produktion.

För att uppfylla projektets olika mål krävdes ett brett arbetssätt för att inhämta information och data. Praktiskt arbete och praktik i produktionen i EFA har kombinerats med intervjuer och datainsamling från arkiv, dokument samt genom användning av olika datorprogram.

Place, publisher, year, edition, pages
2017.
Keywords [sv]
Lösningsmedel, utströmmar, AstraZeneca, produktionseffektivisering, avfall
National Category
Other Chemistry Topics
Identifiers
URN: urn:nbn:se:kth:diva-215511OAI: oai:DiVA.org:kth-215511DiVA, id: diva2:1148229
External cooperation
AstraZeneca
Available from: 2017-10-10 Created: 2017-10-10 Last updated: 2017-10-10Bibliographically approved

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